对比分析米非司酮周期疗法与孕激素治疗围绝经期功血的效果

Comparative Analysis of the Effects of Mifepristone Cycle Therapy and Progesterone on Perimenopausal Uterine Bleeding

目的观察米非司酮周期疗法与孕激素治疗围绝经期功血的效果。方法该院2018年8月—2019年8月收治的44例围绝经期功能失调性子宫出血患者为该次研究对象,按照双色球随机分配原则将患者分为对照组(22例:孕激素治疗)与实验组(22例:米非司酮周期疗法),比较两组患者预后效果。结果实验组患者持续给药治疗3个月后黄体素(P)、雌激素(E2)、黄体生成素(LH)等性激素指标且治疗后子宫内膜厚度明显均优于对照组,数据差异有统计学意义(t=18.151、17.635、14.315、10.463,P<0.05)。实验组患者持续给药3个月后不良反应发生率(9.10%)低于对照组,停药后6个月月经正常率(68.18%)高于对照组,数据差异有统计学意义(χ^2=5.309、5.468,P<0.05)。结论围绝经期功血患者米非司酮周期疗法治疗效果明显优于孕激素治疗效果。

Objective To observe the effect of mifepristone cycle therapy and progesterone on perimenopausal dysfunctional uterine bleeding.Methods 44 patients with perimenopausal dysfunctional uterine bleeding admitted to the hospital from August 2018 to August 2019 were the subjects of this study.The patients were divided into control group(22 cases:progesterone treatment)and the experimental group(22 cases:mifepristone cycle therapy)according to the principle of random allocation of double-color balls,compare the prognosis of the two groups of patients.Results After 3 months of continuous treatment for patients in the experimental group,lutein(P),estrogen(E2),luteinizing hormone(LH)and other sex hormone indicators,and the endometrial thickness after treatment were significantly better than those in the control group,the data was different;the difference was statistically significant(t=18.151,17.635,14.315,10.463,P<0.05).The incidence of adverse reactions(9.10%)of patients in the experimental group after continuous administration for 3 months was lower than that of the control group,and the normal menstrual rate(68.18%)after stopping the drug for 6 months was higher than that of the control group.The data difference was statistically significant(χ^2=5.309,5.468 P<0.05).Conclusion The therapeutic effect of mifepristone cycle therapy in patients with perimenopausal dysfunctional dysfunctional uterine bleeding is significantly better than that of progesterone.