四逆酸枣仁合方治疗失眠肝郁血虚证的临床疗效观察

Clinical observation of Compound Sini Suanzaoren Decoction in the treatment of insomnia due to liver stagnation and blood deficiency

目的观察四逆酸枣仁合方与艾司唑仑治疗失眠肝郁血虚证的临床疗效。方法收集肝郁血虚证失眠患者60例。随机分为四逆酸枣仁合方组和艾司唑仑组(西药组)。使用匹兹堡睡眠指数量表(PSQI)、汉密顿抑郁量表(HAMD)、中医证候调查表,对患者进行服药前后对比。结果四逆酸枣仁合方组治疗肝郁血虚型失眠患者治疗前患者PSQI总评分为(11.53±2.22)分,治疗后为(6.16±2.00)分,差异有统计学意义(P<0.05),西药组治疗前患者PSQI总评分为(11.30±2.49)分,治疗后为(6.10±2.40)分,差异具有统计学意义(P<0.05)。患者HAMD得分结果中,2组治疗前后差异均具有显著(P<0.05),治疗后2组组间比较结果无显著性差异(P>0.05)。中医证候量表结果表明合方组改善患者中医症状较优于对照组。结论四逆酸枣仁合方治疗失眠肝郁血虚证具有较好的临床疗效,可以进一步探究其临床疗效及作用机制。

Objective To observe and compare the clinical efficacy of Compound Sini Suanzaoren Decoction and Estazolam in the treatment of insomnia due to stagnation of liver and deficiency of blood.Methods 60 cases of insomnia due to stagnation of liver and deficiency of blood were collected.They were randomly assigned to the compound Sini Suanzaoren Decoction treatment group and Estazolam treatment group(Western medicine group).Pittsburgh Sleep Quality Index(PSQI),Hamilton Depression Scale(HAMD)and TCM Syndrome Questionnaire were used to compare the patients before and after taking medicine.Results There were significant differences between the two groups before and after treatment(P<0.05)in the total score of Pittsburgh Sleep Quality Index(PSQI)and the score of Hamilton Depression Scale(HAMD).There was no significant difference between the two groups after treatment(P>0.05).The improvement of TCM symptoms was better in the compound prescription group than in the control group.Conclusions Compound Sini Suanzaoren Decoction has good clinical efficacy in treating insomnia due to stagnation of liver and deficiency of blood.