IL-17拮抗剂在银屑病亚型治疗中的研究进展

The Research Progress of IL-17 Antagonist in the Treat-ment of Psoriasis

银屑病是一种免疫介导的慢性、系统性、炎症性疾病。近年来研究表明,IL-17在银屑病的发病机制中起着重要作用,可作为治疗银屑病的靶点。本文系统阐述IL-17拮抗剂治疗中重度斑块型银屑病、关节病型银屑病、脓疱型银屑病以及红皮病型银屑病的临床疗效及安全性,为中重度银屑病提供靶向治疗策略。

Psoriasis is a chronic inflammatory,immune-mediated and systemic disease.Recent studies indicate that IL-17 plays an important role in the pathogenesis of psoriasis,and it can serve as a target for the treatment of psoriasis.This article carries on the systematic discussion to the clinical efficacy and safety of IL-17 antagonists in the treatment of moderate to severe psoriasis,psoriatic arthritis,generalized pustular psoriasis and erythrodermic psoriasis.To provide targeted therapy strategy for moderate to severe psoriasis.