银屑病生物治疗的常见问题与对策

Common Problems and Countermeasures in the Treat-ment of Psoriasis with Biologic Agents

生物制剂在银屑病中的应用越来越广泛,已经成为中重症和难治性病例的重要治疗手段,在特殊类型银屑病的治疗中也发挥着积极的作用。临床实践中,不同患者的病情和个体情况千差万别,在是否应用生物制剂、选择何种生物制剂以及具体的使用方法和安全性等方面还存在各种各样的问题需要解决,临床医生应从患者病情与健康背景、治疗需求和既往治疗反应、生物制剂作用机制和安全性特点等多方面进行综合评估,做出恰当的选择。

With expanding applications for psoriasis indications,biologic agents have become an essential remedy for moderate-to-severe cases,and played a positive part in special type psoriasis.However,in clinical practice,disease condition and individual situation varies from patient to patient,thus healtheare providers still face a lot of challenges when it comes to if it's the time to use biologics,what's the best choice,how to use a biologic agent and if it's safe enough,etc.Clinicians should make appropriate choice based on comprehensive assessment encompassing the patient's disease condition and overall health,demand for treatment,previous therapeutic response,and mechanism of action and safelty characteristics of biologics.