血清25-羟维生素D水平与前庭神经炎的相关性研究

Serum 25-hydroxyvitamin D levels are associated with vestibular neuritis

前庭神经炎(VN)是一种急性发作的自发性及周围性眩晕,可伴有眼震、恶心、呕吐及平衡障碍,但无耳蜗及中枢神经系统症状。在周围性眩晕中,其发病率仅次于良性阵发性位置性眩晕(BPPV)及梅尼埃病(MD)。近年来,大量体外、动物和人体研究结果显示,血清25-羟维生素D[25-(OH)D]参与VN炎症的激活、增殖和分化以及免疫调节的生理过程,血清25-(OH)D水平的缺乏与VN的发病有密切关系,本文系统地回顾了国内外相关文献,对维生素D水平缺乏影响VN发病机制的研究进展进行综述,并提出目前VN治疗中存在的问题,为临床工作中对VN的诊治提供新思路。

Vestibular neuritis(VN) is an acute, spontaneous, peripheral dizziness that can be accompanied by nystagmus, nausea, vomiting and disturbance of balance, but without cochlear and central nervous system symptoms. The incidence of peripheral vertigo is second only to benign paroxysmal positional vertigox(BPPV) and meniere disease(MD). In recent years, a large number of in vitro, animal, and human studies had shown that serum 25-hydroxyvitamin D was involved in the physiological processes of VN-regulated inflammation activation, proliferation and differentiation, and immune regulation. The lack of serum 25-hydroxyvitamin D was closely related to the pathogenesis of VN.This paper systematically reviewed the relevant literature at home and abroad, which summarized the research progress on the pathogenesis of VN affected by vitamin D deficiency.In this paper, the existing problems in the treatment of VN were proposed,and which was providing new ideas for the diagnosis and treatment of VN in clinical work.