高压氧预处理对化疗患者注意网络功能的影响

Hyperbaric oxygen preconditioning improves attention network functioning after chemotherapy

目的观察高压氧预处理对化疗患者注意网络功能的影响。方法选取肿瘤化疗患者共68例,按随机数字表法分为化疗前高压氧预处理组(HBOPC组)22例、高压氧同步化疗组(HBOSC组)26例和不接受高压氧治疗的对照组(对照组)20例,在化疗6个周期后,对3组患者进行注意网络功能(ANT)测试。结果治疗后,HBOPC组和HBOSC组的警觉网络效率均显著高于对照组,差异均有统计意义(P<0.05)。治疗后,HBOPC组和HBOSC组的执行控制网络效率均显著低于对照组,差异均有统计意义(P<0.05),且HBOPC组的执行控制网络效率与HBOSC组比较,差异亦有统计学意义(P<0.05)。治疗后,HBOPC组和HBOSC组的总反应时均显著低于对照组,差异均有统计意义(P<0.05),且HBOPC组治疗后的总反应时为(648.00±85.16)ms,与HBOSC组治疗后比较,差异亦有统计学意义(P<0.05)。结论高压氧治疗可有效地减轻化疗患者的警觉网络和执行控制网络功能损害,相对于HBOSC,HBOPC对患者执行控制网络功能的保护更明显。

Objective To investigate the effect of hyperbaric oxygen preconditioning on attention network functioning after chemotherapy.Methods A total of 68 patients scheduled to receive chemotherapy were randomly divided into a hyperbaric oxygen preconditioning group(HBOPC,n=22),a hyperbaric oxygen sensitizing chemotherapy group(HBOSC,n=26),and a control group(n=20).After 6 cycles of chemotherapy,the attention network test was administered to the patients in all three groups.Results After the treatment,the average alerting efficiencies of the HBOPC and HBOSC groups were significantly higher than that of the control group.Their executive control was also significantly better.There were also significant differences in executive control between that the HBOPC and HBOSC groups,with the HBOPC group performed better.The post-treatment total reaction times of both the HBOPC and HBOSC groups were significantly shorter than that of the control group.That of the HBOPC group was significantly shorter than the HBOSC group′s total.Conclusions Hyperbaric oxygen therapy can effectively reduce network function damage in terms of alerting and executive control.HBOPC protects executive control better than HBOSC.