高通量组学技术在尘螨研究中的应用进展

Applications of high-throughput omics technology in research on dust mite

尘螨是全球最常见的吸入性变应原之一。近20年来,尘螨过敏的患病率呈上升趋势。随着后基因时代的到来,生命科学研究进入到系统、全面、动态的探索阶段。高通量组学采用测序技术从基因、蛋白质等层面对样品进行全面系统的分析和数据挖掘,解释生物学过程的内在机制。本文对尘螨基因组、转录组、蛋白质组、微生物组等4个方面的进展进行综述,为进一步深入研究尘螨过敏原与过敏性疾病、开发新的防治策略提供思路。

House dust mites are one of the most common inhaled allergens worldwide.Since the last 20 years,the prevalence of dust mite allergy has shown a trend of increase.With the advent of the post-genome age,research in life sciences has entered a new stage of systematic,comprehensive and dynamic exploration.High-throughput omics technology has been applied to comprehensively analyze samples at the gene and/or protein levels by sequencing for data mining,and interpreting intrinsic mechanisms of biological processes.This paper reviews the advance in application of high-throughput omics in the genomics,transcriptomics,proteomics and microbiology of dust mites,providing ideas forfurther research on dust mite allergens and allergic diseases and for the development of new control strategies.