ZEB2与E-cadherin在前列腺癌发生、发展中的表达意义

Significance of ZEB2 and E-cadherin in the occurrence and development of prostate cancer

目的研究E盒结合锌指蛋白2(ZEB2)与E-钙黏蛋白(E-cadherin)在前列腺癌发生、发展中的表达意义。方法选取河北省唐山市协和医院2016年1月—2019年3月88例前列腺标本,其中60例前列腺癌组织为观察组,28例良性前列腺增生组织为对照组,采用免疫组化SP法检测两组患者ZEB2、E-cadherin蛋白表达。分析ZEB2和E-cadherin蛋白表达与前列腺癌临床病理参数的关系。结果两组ZEB2、E-cadherin蛋白阳性表达率比较,差异有高度统计学意义(P<0.01)。ZEB2、E-cadherin蛋白的表达与前列腺癌患者TNM分期和骨转移密切相关(P<0.05或P<0.01),而与年龄和Gleason分级无关(P>0.05)。Spearman等级相关分析显示,前列腺癌组织中ZEB2与E-cadherin蛋白的表达呈负相关(r=-0.377,P<0.01)。结论ZEB2蛋白的高表达与E-cadherin蛋白的表达降低在前列腺癌的发生、发展中可能发挥重要作用。

Objective To study the expression significance of zinc-finger E-box binding protein 2(ZEB2)and E-cadherin in the occurrence and development of prostate cancer.Methods A total of 88 prostate specimens from Tangshan Union Medical College Hospital from January 2016 to March 2019 were selected.Among them,a total of 60 prostate cancer tissues were in the observation group and a total of 28 benign prostate hyperplasia tissues were in the control group.The immunohistochemical SP method was used to detect ZEB2 and E-cadherin protein in the two groups.The relationship between ZEB2 and E-cadherin protein expression and clinicopathological parameters of prostate cancer were analyzed.Results The positive expression rate of ZEB2 and E-cadherin between the two groups were compared,and the differences were highly statistically significant(P<0.01).The expression of ZEB2 and E-cadherin protein were closely related to the TNM staging and bone metastasis of prostate cancer patients(P<0.05 or P<0.01),but had nothing to do with age and Gleason grade(P>0.05).Spearman rank correlation analysis showed that ZEB2 and E-cadherin protein expression in prostate cancer tissue were negatively correlated(r=-0.377,P<0.01).Conclusion The high expression of ZEB2 protein and the reduced expression of E-cadherin protein may play an important role in the occurrence and development of prostate cancer.