甲泼尼龙联合艾拉莫德治疗老年原发性干燥综合征患者的临床效果

Clinical effects of Methylprednisolone combined with Iguratimod in treatment of senile primary Sjogren’s syndrome

目的:观察甲泼尼龙联合艾拉莫德治疗老年原发性干燥综合征患者的临床效果。方法:选取80例老年原发性干燥综合征患者为研究对象,采用随机数字表法分成研究组和对照组,每组40例。对照组予甲泼尼龙联合硫酸羟氯喹治疗,研究组予甲泼尼龙联合艾拉莫德治疗,比较两组临床疗效,治疗前后类风湿因子(RF)、免疫球蛋白G(IgG)、抗心磷脂抗体(ACL)水平,以及不良反应发生率。结果:研究组治疗总有效率为92.50%,高于对照组的75.00%,差异有统计学意义(P<0.05);治疗后,两组RF、IgG及ACL水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率为5.00%,低于对照组的20.00%,差异有统计学意义(P<0.05)。结论:甲泼尼龙联合艾拉莫德治疗老年原发性干燥综合征患者效果较好,可改善免疫功能,并可降低不良反应发生率。

Objective:To explore clinical effects of Methylprednisolone combined with Iguratimod in treatment of senile primary Sjogren’s syndrome.Methods:80 senile patients with primary Sjogren’s syndrome were selected as the research objects,and divided into study group and control group by using the random number table method,40 cases in each group.The control group was treated with Methylprednisolone combined with Hydroxychloroquine sulfate,while the study group was treated with Methylprednisolone combined with Iguratimod.The clinical efficacy,the levels of rheumatoid factor(RF),immunoglobulin G(IgG),and anticardiolipin antibody(ACL)before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 92.50%,which was higher than 75.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of RF,IgG and ACL in the two groups were lower than those before the treatment;those of the study group were significantly lower than those of the control group;and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the study group was 5.00%,which was lower than 20.00%in the control group,and the difference was statistically significant(P<0.05).Conclusions:Methylprednisolone combined with Iguratimod is effective in the treatment of the senile patients with primary Sjogren’s syndrome.Moreover,it can improve the immune function and reduce the incidence of adverse reactions.