常见风湿免疫病女性患者血尿酸水平及空腹血糖水平分析

Analysis of serum uric acid and fasting blood glucose level in female patients with common rheumatic immune diseases

目的检测常见风湿免疫病女性患者血尿酸水平及空腹血糖水平,并与正常女性的相关指标进行对比分析,旨在了解风湿免疫病患者代谢状况,为临床治疗提供一定借鉴。方法收集2017年9月-2019年9月安徽省阜阳市人民医院风湿免疫科住院女性患者共300例[系统性红斑狼疮(systemic lupus erythematosus,SLE)50例、狼疮性肾炎(lupus nephritis,LN)50例、原发性干燥综合征(primary Sj9gren’s syndrome,pSS)50例、类风湿性关节炎(rheumatoid arthritis,RA)50例、脊柱关节炎(spondyloarthritis,SpA)50例、特发性炎症性肌病(idiopathic inflammatory myopathy,IIM)50例]的临床资料,检测患者血尿酸和空腹血糖水平,应用计算机随机数字表,随机抽取我院体检中心同期体检的50例健康体检女性作为对照组。结果 6组不同类别风湿病女性患者与对照组的血尿酸水平比较差异有统计学意义(F=1.789,P=0.044);进一步行LSD-t检验结果显示,LN患者和健康体检女性相比血尿酸水平明显升高(t=4.622,P<0.001),SpA患者血尿酸水平较健康体检女性降低(t=-2.796,P=0.006);6组不同类别风湿病女性患者空腹血糖水平与健康体检女性比较差异无统计学意义(F=1.112,P=0.712)。结论 LN女性患者的血尿酸水平高于健康女性,SpA女性患者血尿酸水平低于健康女性;不同风湿病女性患者空腹血糖水平与健康女性比较无明显差异,针对LN女性患者要注意随访,警惕肾损伤的出现。

Objective To detect the serum uric acid level and fasting blood glucose level in women with common rheumatism immune disease, and to compare and analyze the relative indexes with those of normal women, so as to understand the metabolic status of patients and provide some references for clinical treatment. Methods The clinical data of 300 female patients in Fuyang People’s hospital from September 2017 and September 2019 were selected, including systemic lupus erythematosus(SLE) 50 cases, lupus nephritis(LN) 50 cases, primary Sj9 gren’s syndrome(pSS) 50 cases, rheumatoid arthritis(RA) 50 cases, spinal arthritis(SpA) 50 cases, and inflammatory myopathy(IIM) 50 cases. Another 50 cases of healthy women in the same period of physical examination in our hospital were randomly selected as the control group. The blood uric acid and fasting glucose level were detected. Results There were significant differences in the serum uric acid levels among 6 groups of female patients with different categories of rheumatic diseases(F=1.789, P=0.044). The LSD-t results showed that the serum uric acid level was significantly increased in LN patients compared with that in normal women(t=4.622, P<0.001), the serum uric acid level of SpA patients was lower than that of normal women(t=-2.796, P=0.006). There was no statistically significant difference in fasting glucose level between the 6 groups compared with that of the normal women(F=1.112, P=0.712). Conclusion The serum uric acid level of female LN patients is higher than that of normal women. The serum uric acid levels in female SpA patients is lower than those in normal women. There is no significant difference between the fasting blood glucose levels of women with different rheumatism and that of healthy women. Follow up should be paid attention to in LN women and the appearance of renal injury should be vigilant.