新型冠状病毒肺炎的胃肠道症状与肝损伤

Gastrointestinal symptoms and liver injury of COVID-19

新型冠状病毒肺炎(COVID-19)由机体感染冠状病毒SARS-CoV-2所导致,主要表现为典型的呼吸系统症状。SARS-CoV-2除了入侵呼吸系统,还会侵犯表达细胞表面受体ACE2的其他器官,消化系统即为SARS-CoV-2的易感靶点。大多数患者在病程中出现消化系统受损的临床症状。COVID-19的胃肠道症状包括厌食、恶心、呕吐、腹泻、腹痛、肝脏损伤等。出现消化系统损伤的患者进展为重症或危重症的几率更大,预后更差,死亡风险更高。本文旨在对COVID-19感染的消化系统症状进行探讨和论述,以期提高在临床诊治和疫情防控过程中对COVID-19患者出现的消化系统异常及胃肠道症状的重视。

COVID-19 is caused by the SARS-COV-2,which characterized with typical respiratory symptoms.In addition to the respiratory system injury,SARS-COV-2 may also invade other organs that express the cell surface receptor ACE2.Digestive system is a susceptible target of SARS-COV-2.Most patients show clinical symptoms of impaired digestive system during the course of the disease.Gastrointestinal symptoms of COVID-19 include anorexia,nausea,vomiting,diarrhea,abdominal pain,and liver damage.Patients with abnormal symptoms of the digestive system have a greater chance of progressing to severe or critical illness,a worse prognosis,and a higher risk of death.This paper aims to discuss the digestive symptoms of COVID-19 infection,so as to improve the attention to the digestive system abnormalities and gastrointestinal symptoms of COVID-19 patients during clinical diagnosis,treatment and prevention and control.