雾化吸入布地奈德与静脉应用甲泼尼龙治疗慢性阻塞性肺疾病的效果比较

Comparison of the effect of nebulized Budesonide and intravenous Methylprednisolone in the treatment of chronic obstructive pulmonary disease

目的探讨布地奈德与沙丁胺醇联合雾化及静脉甲泼尼龙联合沙丁胺醇雾化治疗慢性阻塞性肺疾病的临床效果比较。方法选取2019年3~10月我院诊治100例慢性阻塞性肺疾病患者的临床资料,按治疗方法不同分为两组,研究组予以布地奈德与沙丁胺醇联合雾化治疗,对照组予以静脉应用甲泼尼龙与沙丁胺醇雾化治疗,分析两组患者的治疗效果、肺功能与炎症因子情况。结果治疗后,研究组患者的临床总有效率为96.00%,高于对照组的84.00%,差异有统计学意义(P<0.05);研究组患者的C反应蛋白(CRP)水平低于对照组,且第1秒用力呼气容积(FEV1)及FEV1与用力肺活量(FVC)的比值(FEV1/FVC)高于对照组,差异均有统计学意义(P<0.05)。结论慢性阻塞性肺疾病应用布地奈德与沙丁胺醇联合雾化治疗,相比于静脉甲泼尼龙联合沙丁胺醇雾化治疗,更能有效改善患者的肺功能,降低炎症因子水平,临床应用效果显著。

Objective To explore the comparison clinical effect of the combined atomization of Budesonide and Salbutamol and the intravenous application of Methylprednisolone combined with atomization of Salbutamol in the treatment of chronic obstructive pulmonary disease(COPD).Methods The clinical data of 100 patients with COPD diagnosed and treated in our hospital from March to October 2019 were selected and divided into two groups according to different treatment methods.The study group was treated with combined atomization of Budesonide and Salbutamol,the control group was treated with intravenous application of Methylprednisolone combined with atomization of Salbutamol.The treatment effect,lung function and inflammatory factors of the two groups were analyzed.Results After treatment,the total clinical effective rate in the study group was 96.00%,which was higher than 84.00%in the control group,the difference was statistically significant(P<0.05).The C-reactive protein(CRP)level in the study group was lower than that in the control group,the forced expiratory volume in the first second(FEV1)and the ratio of FEV1 to forced vital capacity(FVC,FEV1/FVC)were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion Combined atomization of Budesonide and Salbutamol for COPD patients is more effective in improving their lung function and reducing their inflammatory factors than intravenous application of Methylprednisolone combined with atomization of Salbutamol,with remarkable clinical effect.