糖化血红蛋白与糖耐量联合检测在妊娠糖尿病诊断中的价值观察

Observation on the value of combined detection of glycosylated hemoglobin and glucose tolerance in diagnosis of gestational diabetes mellitus

目的探讨糖化血红蛋白与糖耐量联合检测在妊娠糖尿病诊断中的价值。方法自我院2018年8月~2019年8月疑似妊娠糖尿病患者中筛选出240例,采用电脑随机分组的方式分组,对照组接受糖耐量检测,研究组接受糖化血红蛋白与糖耐量联合检测,比较两组的检测结果,分析糖化血红蛋白与糖耐量联合检测对妊娠糖尿病的诊断价值。结果240例患者均确诊为妊娠糖尿病(采用空腹血糖测定、糖耐量试验、糖化血红蛋白测定确诊为妊娠糖尿病),比较两组诊断方式的确诊率,对照组的确诊率为80.00%(96/120),低于研究组的99.17%(119/120),差异有统计学意义(P<0.05);研究组的特异性为94.17%(113/120)、敏感性为95.83%(115/120),均高于对照组的特异性84.17%(101/120)、敏感性85.83%(103/120),差异有统计学意义(P<0.05)。结论对于疑似妊娠糖尿病患者,采用糖化血红蛋白与糖耐量联合检测,确诊率高,可作为诊断妊娠糖尿病的诊断依据,有助于临床尽早诊断与干预,减少其对母婴的危害,该诊断方法值得推广。

Objective To investigate the value of combined detection of glycosylated hemoglobin(HbA1C)and glucose tolerance in diagnosis of gestational diabetes mellitus.Methods A total of 240 patients were screened out from patients with suspected gestational diabetes mellitus(GDM)admitted to our hospital from August 2018 to August 2019.The patients were randomly divided into groups by computer.The control group received glucose tolerance test,while the study group received combined detection of glycosylated hemoglobin and glucose tolerance.The test results of the two groups were compared,and the diagnostic value of combined detection of glycosylated hemoglobin and glucose tolerance for GDM were analyzed.Results All the 240 patients were confirmed as GDM(GDM) was confirmed by fasting blood glucose test,glucose tolerance test and determination of glycosylated hemoglobin(HbA1c).The diagnostic rate of two groups were compared,and that of the control group was 80.00%(96/120),which was lower than 99.17%(119/120)of the study group.The difference was statistically significant(P<0.05).The specificity and sensitivity of the study group were 94.17%(113/120)and 95.83%(115/120),which were higher than 84.17%(101/120)and 85.83%(103/120)of the control group,respectively(P<0.05).Conclusion For patients with suspected GDM,the combined detection of HbA1C and glucose tolerance has a high diagnostic rate,which can be used as a diagnostic basis for GDM.It is helpful for early clinical diagnosis and intervention,and reducing the harm to mother and infant,which is worth promoting.