血小板相关参数对慢性肾脏病患者微炎症状态的临床意义

The clinical significance of platelet-related parameters for micro-inflammatory state of the patients with chronic kidney disease

目的探讨血小板相关参数与慢性肾脏病(CKD)患者微炎症状态的关系。方法选取2018年1月~2019年12月潮州市人民医血液净化中心就诊的维持性血液透析(MHD)治疗(透析龄>3个月)患者为MHD组(n=72),同期确诊的慢性肾脏病3期或4期的患者作为透析前组(n=40),同期的健康体检者作为健康组(n=41)为研究对象,收集所有研究对象的一般临床资料及实验室指标,比较三组数据间的差异并进行统计学分析。结果透析前组和MHD组的血小板平均体积(MPV)水平均低于健康组,差异有统计学意义(P<0.05);三组间血小板分布宽度(PDW)和血小板平均体积/血小板计数比值(MPV/PLT)水平比较,差异无统计学意义(P=0.723、0.166);MPV/PLT与hs-CRP呈正相关(r=0.185,P=0.022),与TG、TC和LDL-C均呈负相关(r=-0.172,P=0.033;r=-0.232,P=0.004;r=-0.169,P=0.037),与Hb、ALB、HDL-C无统计学相关性。结论MPV/PLT在评价CKD患者微炎症状态方面具有潜在的临床价值。

Objective To explore the relationship between platelet-related parameters and micro-inflammatory state of the patients with chronic kidney disease(CKD).Methods The maintenance hemodialysis(MHD)patients(dialysis ages>3 months)treated in the blood purification center of Chaozhou People's Hospital from January 2018 to December 2019 were selected as the MHD group,the patients diagnosed with stageⅢorⅣCKD and the healthy people had health checkupduring the same period were selected as the pre-dialysis group and the healthy group.Date on patients demographics and laboratory parameters were registeres.All data were statistically analyzed.Results Compared to healthy subjects,the levels of mean platelet volume(MPV)were statistically significantly lower in pre-dialysis group and CKD group(P<0.05).The distribution width(PDW)and mean platelet volume/platelet count ratio(MPV/PLT)among the three groups were statistically insignificant(P=0.723,0.166).The MPV/PLT was positively correlated with hs-CRP(r=0.185,P=0.022),negatively correlated with TG,TC and LDL-C(r=-0.172,P=0.033;r=-0.232,P=0.004;r=-0.169,P=0.037),and not statistically correlated with Hb,ALB and HDL-C.Conclusion MPV/PLT has potential clinical value for evaluating microinflammatory state of the patients with CKD.