摘要
Hypoxia is a common feature of the most solid tumors attributing to the rapid growth and abnormal proliferation of the vascular system[1],which unfortunately causes the resistance of tumor cells to oxygen-dependent cancer-therapeutic modalities,such as the well-known and well-demonstrated radiotherapy(RT)and photodynamic therapy(PDT)[2].In particular,the therapeutic efficacy of PDT has been substantially restricted by hypoxia based on the limited conversion of oxygen(O2)to reactive oxygen species(ROS)that usually deteriorates the degree of hypoxia in turn.
作者
Hui Hu
Xiaoqin Qian
Yu Chen
胡慧;钱晓芹;陈雨(Medmaterial Research Center,Jiangsu University Affiliated People’s Hospital,Zhenjiang 212002,China;School of Life Sciences,Shanghai University,Shanghai 2000444,China;State Key Lab of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,China)
基金
National Key R&D Program of China(2016YFA0203700)
the National Natural Science Foundation of China(51672303,81971629,and 81771848)
Excellent Young Scientist Foundation of National Natural Science Foundation of China(51722211)
Shanghai Sailing Program(81901752)
Program of Shanghai Subject Chief Scientist(18XD1404300)。
