体育锻炼对阿尔茨海默病患者生化指标及日常生活能力的影响

Effect of physical exercise on the biochemical indicators and daily life ability of patients with Alzheimer's disease

目的探讨体育锻炼对阿尔茨海默病患者生化指标、日常生活能力的影响.方法将52例阿尔茨海默病患者按体育锻炼状况分为两组,体育锻炼组23例,非体育锻炼组29例.于患者入院时统计一般人口学资料,并进行血常规、生化指标等实验室检测,采用日常生活能力量表及护士观察量表评定两组患者的日常生活能力、暴力风险及易激惹状况.结果两组患者病程、化验指标(血红蛋白、总胆红素、直接胆红素、白蛋白、白球比、胰岛素、血清胱抑素C、尿a1微球蛋白、血β2微球蛋白、载脂蛋白A、乳酸脱氢酶、磷酸肌酸激酶、血钙、游离三碘甲状腺原氨酸、游离甲状腺素)检测结果比较差异有统计学意义(P<0.05或0.01)、日常生活能力量表总分、护士观察量表的暴力风险及激惹评分比较差异有统计学意义(P<0.05或0.01).两组美金刚、多奈哌齐、劳拉西泮应用状况比较差异有统计学差异(P<0.01).结论体育锻炼能明显改善阿尔茨海默病患者的生化指标及日常生活能力.

Objective To explore the impact of physical exercise on the biochemical indicators and daily living ability of patients with Alzheimer's disease.Methods 52 AD patients were divided into two groups according to their physical exercise status,with 23 cases in the physical exercise group and 29 in the non-physical exercise group.Collect general demographic data when patients admitted to the hospital,and per-form laboratory tests such as blood routine and bioche mical indicators.ADL.and NOSIE were used to as-sess the ability of daily living.risk of violence and irritability of the two groups of patients.Results There was a statistically significant difference in the course of disease and test results of laboratory indica-tors(hemoglobin,total bilirubin,direct bilirubin,albumin.ALB,insulin,serum cystatin C.urine al mi-croglobulin,bloodβ2 microglobulin,apolipoprotein A.lactate dehydrogenase,creatine phosphate Kinase,blood calcium,free triodothyronine,free thyroxine)between the two groups(P<0.05 or 0.01).ADL.total score.NOSIE violence risk and agitation scores were significantly different(P<0.05 or 0.01)。There were significant differences in the application status of memantine,donepezil and lorazepam between the two groups(P<0.01).Conclusions Physical exercise can significantly improve the physiological indi-cators and activities of daily living in patients with Alzheimer's disease.