前列腺癌手术去势与药物去势对临床疗效及PSA的影响

Effect of Surgical and Drug Castration on Clinical Efficacy and PSA for Prostate Cancer

目的探析前列腺癌手术去势与药物去势对临床疗效及PSA的影响。方法方便选取该院于2016年8月—2019年6月收治的50例前列腺癌患者作为研究对象,采用数字随机表法将其分为对照组和观察组,各25例。观察组采用药物去势治疗,对照组采用手术去势治疗,对比两组的临床疗效、血清前列腺特异性抗原改善情况、不良反应发生率及生活质量评分。结果经对比两种治疗方法的临床疗效,观察组与对照组的治疗有效率(84.0%vs 68.0%)对比,差异无统计学意义(χ^2=1.754,P>0.05);两组患者治疗前后的血清前列腺特异性抗原水平对比差异无统计学意义(P>0.05),治疗后较治疗前明显改善,且观察组优于对照组,差异有统计学意义(P<0.05);观察组患者的不良反应发生率低于对照组(4.0%vs 24.0%),差异有统计学意义(χ^2=4.153,P<0.05);观察组患者的生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论在前列腺癌的治疗上,手术去势和药物去势均可获得一定的治疗效果,但相比于手术去势,采用药物去势治疗可改善患者的前列腺特异性抗原水平,同时可改善患者的生活质量。

Objective To explore the effects of surgical castration and medical castration of prostate cancer on clinical efficacy and PSA.Methods Fifty patients with prostate cancer admitted to the hospital from August 2016 to June 2019 were convenient selected as the main research subjects,and they were divided into a control group and an observation group with 25 cases in each group using a digital random table method.The observation group was treated with medical castration,and the control group was treated with surgical castration.The clinical efficacy,improvement of serum prostate specific antigen,incidence of adverse reactions and quality of life scores were compared between the two groups.Results After comparing the clinical efficacy of the two treatment methods(84.0%vs 68.0%),there was no statistically significant difference between the two group(χ^2=1.754,P>0.05);there was no statistically significant difference in serum prostate-specific antigen levels before and after treatment(P>0.05).After treatment,it was significantly improved compared with before treatment.The observation group was better than the control group,and the difference was statistically significant(P<0.05);the incidence of adverse reactions in the observation group was lower than the control group(4.0%vs 24.0%),the difference was statistically significant(χ^2=4.153,P<0.05);the observation group had a higher quality of life score than the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of prostate cancer,both surgical castration and medical castration can achieve certain therapeutic effects.However,compared with surgical castration,the use of medical castration can improve the patient's prostate specific antigen level and the quality of life.