三阴型乳腺癌改良根治术后T1~T2N1M0行辅助性放疗的效果研究

Study on the Effect of Adjuvant Radiotherapy on T1-T2N1M0 after Modified Radical Mastectomy for Triple Negative Breast Cancer

目的T1~T2N1M0期三阴型乳腺癌改良根治术后辅助性放疗的临床效果。方法方便选取2014年1月—2018年12月该院68例T1~T2N1M0期三阴型乳腺癌患者为研究对象,全部患者均行乳腺癌改良根治术,术后常规化疗,依据是否行术后放疗分为实验组(术后行辅助放疗,34例)和对照组(术后未行辅助放疗,34例),比较观察两组复发转移情况,评价疗效,统计并发症。结果随访期间,实验组肿瘤局部复发率(20.59%)、远处转移率(14.71%)、5年生存率(88.24%)均优于对照组,差异有统计学意义(χ^2=4.836、5.916、4.66,P<0.05)实验组患者无病生存时间为(25.7±3.2)个月,优于对照组(P<0.05),实验组患者放射性皮炎发生率29.41%,经积极治疗未影响放疗进程。结论T1~T2N1M0期三阴型乳腺癌改良根治术后行辅助性放疗效果确切,可有效减少肿瘤复发与转移,延长无病生存时间,值得使用推广,但患者放射性皮炎发生率较高,治疗期间需加强对症处理。

Objective The clinical effect of adjuvant radiotherapy after modified radical mastectomy for T1-T2N1M0 stage triple negative breast cancer.Methods From January 2014 to December 2018,68 patients with T1-T2N1M0 triple-negative breast cancer in the hospital were studied.All patients underwent modified radical mastectomy and conventional postoperative chemotherapy,depending on whether postoperative radiotherapy was performed.Divided into the experimental group(adjuvant radiotherapy after operation,34 cases)and the control group(no adjuvant radiotherapy after operation,34 cases),to compare and observe the recurrence and metastasis of the two groups,evaluate the efficacy,and count complications.Results During follow-up,the local tumor recurrence rate(20.59%),distant metastasis rate(14.71%)and 5-year survival rate(88.24%)of the experimental group were better than those of the control group.The difference was statistically significant(χ^2=4.836,5.916,4.66,P<0.05).The disease-free survival time of the experimental group was(25.7±3.2)months,which was better than that of the control group(P<0.05);the incidence of radiation dermatitis in the experimental group was 29.41%,active treatment did not affect the progress of radiotherapy.Conclusion Adjuvant radiotherapy after modified radical mastectomy for T1-T2N1M0 triple-negative breast cancer has a definite effect.It can effectively reduce tumor recurrence and metastasis and prolong disease-free survival.It is worthy of promotion.However,the incidence of radiation dermatitis in patients is higher during treatment,and it needs to strengthen symptomatic treatment.