抗生素所致不良反应及临床合理用药分析

Analysis of Adverse Reactions Caused by Antibiotics and Clinical Rational Drug Use

目的分析抗生素所致不良反应及临床合理用药。方法回顾分析该院自2018年5月—2019年5月临床收治的抗生素所致不良反应的患者98例,研究导致不良反应的抗生素种类以及不良反应的各种相关症状,并对临床合理用药提出一些有效的措施。结果在抗生素不良反应发生率上60~75周岁的患者所占比例最高,达到了33.69%。头孢菌素类抗生素所致的不良反应发生率最高,其次是青霉素类抗生素。抗生素所致的不良反应累及到患者的皮肤及附件系统、消化系统、神经系统、心血管系统以及呼吸系统。结论抗生素使用不当容易导致不良反应的发生,不良反应对人体各器官造成的影响很大,因此临床应加大对抗生素所致不良反应及临床合理用药的分析,从而降低不良反应发生率,提高药物安全性。

Objective To analyze the adverse reactions caused by antibiotics and the clinical rational use of drugs.Methods A retrospective analysis of 98 patients with adverse reactions caused by antibiotics clinically admitted in the hospital from May 2018 to May 2019,to study the types of antibiotics that caused adverse reactions and various related symptoms of adverse reactions,and to propose clinical rational use of drugs and effective measures.Results In the incidence of adverse antibiotic reactions,the proportion of patients aged 60-75 years was the highest,reaching 33.69%.The incidence of adverse reactions caused by cephalosporin antibiotics was the highest,followed by penicillin antibiotics.Adverse reactions caused by antibiotics affect the patient's skin and accessory system,digestive system,nervous system,cardiovascular system and respiratory system.Conclusion Improper use of antibiotics can easily lead to adverse reactions,which have a great impact on various organs of the human body.Therefore,clinical analysis of adverse reactions caused by antibiotics and clinical rational drug use should be increased in order to reduce the incidence of adverse reactions and improve drugs safety.