舍曲林治疗青少年抑郁症的开放性研究

An Open Study of Sertraline in the Treatment of Adolescent Depression

目的探讨曲舍林治疗青少年抑郁症的临床效果。方法方便选取2017年10月—2019年10月该院收治的94例青少年抑郁症患者为研究对象,随机分为实验组(口服曲舍林治疗,47例)和对照组(口服氟西汀治疗,47例),观察两组干预前后HAMD量表、BDI量表评分变化,以LOTCA量表评估认知功能改善情况,PSQI量表评估睡眠改善情况,CGI量表评估两组治疗情况,另测定治疗前后两组血清CRP水平,统计不良反应。结果两组HAMD、BDI、LOTCA、CGI-SI、CGI-GI量表评分差异无统计学意义(P>0.05);实验组治疗后PSQI量表(5.0±1.7)分,CGI-EI评分(3.2±0.6)分,血CRP水平(3.7±1.6)g/L均优于对照组,差异有统计学意义(t=2.684、2.796、2.833,P<0.05);实验组不良反应率为4.26%,优于对照组(χ^2=3.411,P<0.05)。结论舍曲林治疗青少年抑郁症临床效果确切,对改善患者睡眠、降低血清C反应蛋白也具有积极作用,不良反应少,安全性高,可作为青少年抑郁症理想治疗药物加以推广使用。

Objective To explore the clinical effect of troseline in the treatment of adolescent depression.Methods A total of 94 adolescent depression patients admitted to the hospital from October 2017 to October 2019 were convenient selected as the research subjects,and they were randomly divided into an experimental group(oral troseline treatment,47 cases)and a control group(oral fluoxetine treatment,47 cases),observe the changes in the scores of the HAMD scale and BDI scale before and after the intervention of the two groups,use the LOTCA scale to evaluate the improvement of cognitive function,the PSQI scale to evaluate the improvement of sleep,the CGI scale to evaluate the treatment of the two groups,and determine the before and after treatment The serum CRP levels of the two groups were counted for adverse reactions.Results There was no significant difference in HAMD,BDI,LOTCA,CGI-SI,CGI-GI scale scores between the two groups(P>0.05);the experimental group had PSQI score(5.0±1.7)points after treatment,and CGI-EI score(3.2±0.6)points,blood CRP levels(3.7±1.6)g/L were better than those of the control group,the difference was statistically significant(t=2.684,2.796,2.833,P<0.05);the adverse reaction rate of the experimental group was 4.26%,Better than the control group(χ^2=3.411,P<0.05).Conclusion Sertraline has a definite clinical effect in the treatment of adolescent depression.It also has a positive effect on improving patients'sleep and lowering serum C-reactive protein,with few adverse reactions and high safety.It can be promoted as an ideal treatment for adolescent depression.