超敏C反应蛋白、类风湿因子、抗环瓜氨酸肽抗体联合血清淀粉样蛋白A检测对类风湿性关节炎患者的诊断价值

Diagnostic Value of High Sensitive C-reactive Protein,Rheumatoid Factor,Anti Cyclic Citrullinated Peptide Antibody Combined with Serum Amyloid A in Patients with Rheumatoid Arthritis

目的探讨超敏C反应蛋白、类风湿因子、抗环瓜氨酸肽抗体联合血清淀粉样蛋白A检测在类风湿性关节炎诊断中的应用价值。方法选取我院(2017年1月至2019年1月)收治的50例RA患者为观察组,另选取50例同时期来我院体检健康者为对照组,对比两组患者SAA、抗CCP抗体、RF、hs-CRP水平和单项及联合检测阳性率。结果观察组SAA、抗CCP抗体、RF、hs-CRP水平分别为(185.10±36.83)mg/L、(110.24±46.33)RU/mL、(248.60±63.83)U/mL、(81.98±36.83)mg/L。对照组SAA、抗CCP抗体、RF、hsCRP水平分别为(5.71±2.39)mg/L、(26.93±10.83)RU/mL、(4.45±2.63)U/mL、(4.45±2.33)mg/L,观察组SAA、抗CCP抗体、RF、hs-CRP水平明显高于对照组(t=24.3692、12.3813、17.0239、14.8554,P <0.05)。观察组SAA、抗CCP抗体、RF、hs-CRP单项及联合阳性检出率分别为41例(82.00%)、35例(70.00%)、42例(84.00%)、33例(66.00%)、46例(92.00%)。对照组SAA、抗CCP抗体、RF、hs-CRP单项及联合阳性检出率分别为0、21例(42.00%)、0、1例(2.00%)、4例(8.00%)。观察组SAA、抗CCP抗体、RF、hs-CRP单项及联合阳性检出率明显高于对照组,且联合检测阳性率高于单项检测(P <0.05)。结论超敏C反应蛋白、类风湿因子、抗环瓜氨酸肽抗体联合血清淀粉样蛋白A检测在类风湿性关节炎诊断中具有较高的应用价值,联合检测能提升RA检出率。

Objective To explore the value of detection of high sensitive C-reactive protein,rheumatoid factor,anti cyclic citrullinated peptide antibody and serum amyloid A in the diagnosis of rheumatoid arthritis.Methods Fifty RA patients in our hospital(from January 2017 to January 2019)were selected as the observation group,and another 50 healthy people in our hospital during the same period were selected as the control group.The SAA,anti CCP antibody,RF,hs CRP levels and the positive rates of single and joint tests were compared between the two groups.Results The levels of SAA,anti CCP antibody,RF and hs CRP in the observation group respectively were(185.10±36.83)mg/L,(110.24±46.33)RU/mL,(248.60±63.83)U/mL,(81.98±36.83)mg/L.The levels of SAA,anti CCP antibody,RF and hs CRP in the control group respectively were(5.71±2.39)mg/L,(26.93±10.83)RU/mL,(4.45±2.63)U/mL,(4.45±2.33)mg/L.The levels of SAA,anti CCP antibody,RF and hs CRP in the observation group were signifi cantly higher than those in the control group(t=24.3692,12.3813,17.0239,14.8554,P<0.05).The positive rates of SAA,anti CCP antibody,RF and hs CRP respectively were 41 cases(82.00%),35 cases(70.00%),42 cases(84.00%),33 cases(66.00%)and 46 cases(92.00%).The positive rates of SAA,anti CCP antibody,RF and hs CRP in the control group respectively were 0,21 cases(42.00%),0,1 case(2.00%),4 cases(8.00%).The positive rate of SAA,anti CCP antibody,RF,hs CRP in the observation group was signifi cantly higher than that in the control group,and the positive rate of combined test was higher than that of single test(P<0.05).Conclusion The detection of high sensitive C-reactive protein,rheumatoid factor,anti cyclic citrullinated peptide antibody and serum amyloid A has a high value in the diagnosis of rheumatoid arthritis,and the combined detection can improve the detection rate of RA.