不同剂量丙种球蛋白治疗川崎病患者的疗效比较

Efficacy Comparison of Different Dosage of Gamma Globulin in Kawasaki Disease

目的比较不同剂量丙种球蛋白治疗川崎病患者的疗效。方法选取2017年4月至2019年4月方医科大学第五附属医院收治的82例川崎病患儿,根据不同治疗方法将其分为对照组(n=41,采取小剂量连用5 d丙种球蛋白治疗)和研究组(n=41,采取大剂量1 d丙种球蛋白治疗)。比较两组患儿的实验室检查指标、临床症状消失时间及治疗效果。结果治疗前,两组患儿的白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)比较,差异均无统计学意义(P> 0.05);治疗后,研究组患儿的WBC、CRP、PCT均低于对照组,差异均有统计学意义(P <0.05)。研究组黏膜充血、手足肿胀、发热、淋巴肿大症状消失时间及住院时间均短于对照组,差异均有统计学意义(P <0.05)。研究组治疗总有效率为92.68%,高于对照组的78.05%,差异有统计学意义(P <0.05)。结论针对川崎病患儿可采取大剂量丙种球蛋白单日治疗的方式,有助于明显改善患儿的临床症状,缩短康复时间。

Objective To compare the efficacy of diff erent dosage of gamma globulin in Kawasaki disease.Methods Selected 82 children with Kawasaki disease admitted to the Fifth Affiliated Hospital of Fang Medical University from April 2017 to April 2019,and divided them into control groups according to diff erent treatment methods(n=41,with a small dose of 5 d gamma globulin treatment)and the study group(n=41,taking a large dose of 1 d gamma globulin treatment).The laboratory examination indexes,clinical symptoms disappeared time and treatment eff ect of the two groups were compared.Results Before treatment,the white blood cell count(WBC),C-reactive protein(CRP)and procalcitonin(PCT)between groups were not signifi cantly diff erent(P>0.05);after treatment,WBC,CRP and PCT values in the study group were lower than those of control group,with statistically signifi cant diff erence(P<0.05);the relief time of symptoms like mucosal hyperemia,limb swelling,fever and lymph node enlargement as well as hospitalization time in the study group were shorter than those of control group,with statistically signifi cant diff erence(P<0.05);the total eff ective rate in the study group(92.68%)was higher than that of control group(78.05%),with statistically signifi cant diff erence(P<0.05).Conclusion The large-dosage gamma globulin can remarkably improve children's symptoms and shorten the rehabilitation time.