帕金森病伴认知功能损伤的静息态脑网络功能磁共振研究进展

Advances in research on resting brain network functional magnetic resonance imaging for PD with cognitive impairmente

静息态功能磁共振成像(resting state functional magnetic resonance imaging,RSfMRI)研究已普遍运用于分析帕金森病(Parkinson's disease,PD)等神经退行性疾病的病理生理学。有认知损伤的帕金森病患者的功能网络连接发生了一些改变,这些改变可能导致认知功能下降。在该综述中,作者试图总结最近的RS-fMRI研究,讨论早期帕金森病功能连接特征的局限性和潜在意义,以跟踪和预测未来的PD进展。了解临床进展和并发症的神经相关因素和潜在的诱发因素对指导新的临床试验和制定预防策略非常重要。

Resting state functional magnetic resonance imaging(RS-fMRI)has been widely used to analyze the pathophysiology of neurodegenerative diseases such as Parkinson's disease(PD).Parkinson's patients with cognitive impairment experience changes in their functional network connections that can lead to cognitive decline.In this review,we attempt to summarize recent RS-fMRI studies and discuss the limitations and potential significance of functional connectivity features in early Parkinson's disease to track and predict future PD progression.Understanding the neurologic factors and potential triggers of clinical progression and complications is important to guide new clinical trials and develop prevention strategies.