关于痛风性关节炎病证结合动物模型的思考

Reflections on animal model integrated with disease and syndrome for gouty arthritis

病证结合动物模型在中医药实验研究中有着重要的意义,而在模型构建过程中如何实行完整的指标量化是药效评价的基础。本文从中西医临床两方面对痛风性关节炎(gouty arthritis,GA)的认识出发,浅析当前GA动物模型构建的优缺点,总结模型构建过程中所面临的困境,并探讨病证结合动物模型评价指标体系。本文提出血尿酸、肌酐及肝功能可作为GA动物模型的病理量化指标,IL-1、TNF-α等炎症介质可用于评价炎症反应程度,能量代谢相关参数可作为腹胀、纳呆、呕恶等证候量化指标。文章还强调应注重不同证型的特异性指标。

The animal model integrated with disease and syndrome plays an important role in the experimental study of Traditional Chinese Medicine,and how to carry out complete index quantification in the process of model construction is the basis of efficacy evaluation.Based on the understanding of gouty arthritis(GA)in traditional Chinese Medicine and Western Medicine,this paper analyzes the advantages and disadvantages of current GA animal model construction,summarizes the difficulties in the process of model construction,and discusses the evaluation index system in the animal model integrated with disease and syndrome.In this paper,serum uric acid,creatinine and liver function can be used as pathological quantitative indexes of GA experimental animal model,IL-1,TNF-α and other inflammatory mediators can be used to evaluate the degree of inflammatory reaction,and energy metabolism related parameters can be used as quantitative indexes of abdominal distention,anorexia,nausea and other syndromes.The paper also emphasizes that we should pay attention to the specific indexes of different syndrome types.