孕激素及其受体与蜕膜化

Association between Decidualization and Progesterone&Its Receptors

蜕膜化过程精密且复杂,受到激素、细胞和分子信号之间微妙的相互作用。孕激素是调控蜕膜化和胚胎着床的主要调节因子,在子宫内膜蜕膜化过程中起主导地位。在月经周期分泌晚期(月经周期的第24~28天),孕激素(progestogen)结合孕激素受体(progesterone receptor,PR)刺激子宫内膜蜕膜化标志物催乳素(prolactin,PRL)的合成,介导蜕膜化的发生。在复杂的蜕膜化机制中,孕激素与PR主要为控制上皮细胞增殖获得子宫容受性和刺激基质细胞分化建立妊娠。在流产疾病中,妊娠孕激素及孕激素受体的监测对预测妊娠早期胚胎丢失具有指导意义。本文对孕激素和PR在狭义蜕膜化中的作用及其机制进行综述。

Decidualization is a delicate and complex process,which is regulated by hormones and cellular and molecular signals.Progesterone plays a leading role in the process of decidualization and embryo implantation.In the late period of menstrual cycle(the day 24-28 of menstrual cycle),the progesterone combined with progesterone receptor(PR)stimulates the synthesis of prolactin(PRL),a marker of endometrium decidualization,and mediates the occurrence of decidualization.In the complex mechanism of decidualization,progesterone and PR are mainly to control the epithelial cell proliferation to obtain uterine receptivity,and to stimulate stromal cell differentiation to establish pregnancy.The monitoring of progesterone and progesterone receptor has a guiding significance for the prediction of early embryo loss in those patients with habitual abortion.The role of progesterone and PR and the mechanism in decidualization were reviewed in this paper.