神经内镜下经鼻蝶切除术和显微镜切除术治疗垂体瘤的疗效对比

Comparison of Therapeutic Effects Between Endoscopic Transsphenoidal Resection and Microscopic Resection for Pituitary Tumor

目的探究神经内镜与显微镜下的经鼻蝶垂体瘤切除术治疗垂体瘤的疗效。方法选取东海县人民医院2018年1月至2020年1月收治的垂体瘤患者60例为研究对象,根据治疗方法不同分为A组(30例)与B组(30例)。A组采用神经内镜下经鼻蝶入路的垂体瘤切除术治疗,B组采用显微镜下经鼻蝶入路的垂体瘤切除术治疗,对比两组患者的治疗效果指标。结果两组患者的手术时间、术中出血量和术后住院时间比较,A组均低于B组,差异有统计学意义(P<0.001);两组患者术后并发症发生率比较,A组为6.67%,低于B组的30.0%,差异有统计学意义(P<0.05);两组患者术后3周激素水平比较,A组的血清生长激素(GH)、催乳素(PRL)、促肾上腺皮质激素(ACTH)水平均低于B组,差异有统计学意义(P<0.001)。结论神经内镜下的经鼻蝶入路垂体瘤切除术在垂体瘤患者治疗中具有创伤小,术后并发症少的优点,能减轻术后应激反应,促进术后较快恢复。

Objective To explore the efficacy of transnasal sphenoid pituitary tumor resection under neuroendoscopy and microscope in the treatment of pituitary tumors.Methods A total of 60 patients with pituitary tumor admitted to Donghai County People's Hospital from January 2018 to January 2020 were selected as study subjects,and were divided into group A(30 cases)and Group B(30 cases)according to different treatment methods.Group A was treated with neuroendoscopically transsphenoidal approach for pituitary tumor resection,while group B was treated with microscopically transsphenoidal approach for pituitary tumor resection.Therapeutic efficacy indicators of the two groups were comparedd.Results The operative time,intraoperative blood loss and postoperative hospital stay of the two groups were all lower in group A than in group B The difference was statistically significant(P<0.001).The incidence of postoperative complications between the two groups was 6.67%in group A,which was 30.0%lower than that in group B The difference was statistically significant(P<0.05).The levels of GH,PRL and ACTH in group A were lower than those in group B The difference was statistically significant(P<0.001).Conclusion Neuroendoscopic transsphenoidal pituitary adenoma resection has the advantages of less trauma and fewer postoperative complications in the treatment of pituitary adenomas.It can reduce the postoperative stress response and promote the rapid recovery after surgery.