气道平滑肌表观遗传修饰对支气管哮喘的影响

Effect of epigenetic modification of airway smooth muscle on bronchial asthma

支气管哮喘(哮喘)的发生与遗传和环境因素相关,是以慢性气道炎症和气道重塑为特征的疾病。表观遗传学是整合环境暴露和遗传学的关键,目前已成为哮喘研究的一个重要领域。近年来,研究认为组蛋白修饰、甲基化修饰和非编码RNA相关基因沉默是启动和维持表观遗传修饰的机制。气道平滑肌(ASM)增厚是哮喘的一个显著的病理特征,增厚的ASM具备重要合成功能,是炎症趋化因子、生长因子、脂质介质和基质调节剂的丰富来源,在哮喘气道炎症、气道重塑和气道高反应性的发生和发展中发挥重要作用。因此,ASM的表观遗传变化可能导致不同哮喘患者的气道异常反应,从而促进炎症持续和气道重塑恶化。本文就ASM表观遗传修饰对哮喘的影响作一综述。

The occurrence of bronchial asthma(asthma)is related to genetic and environmental factors.The key to integrate environmental exposure and genetics is epigenetics which has become an important field of asthma research at present.In recent years,research suggests that histone modification,methylation modification and the silencing of non-coding RNA-related genes have been considered as mechanisms for initiating and maintaining epigenetic modification.The thickening of Airway smooth muscle(ASM)is a prominent pathological feature of asthma.The thickening of ASM has vital synthetic functions,and it is a rich source of inflammatory chemokines factors,lipid mediators and matrix regulators,it plays an important role in the occurrence and development of asthma airway inflammation,asthma airway remodeling and asthma airway hyperresponsiveness.Therefore,the epigenetic changes of ASM may lead to abnormal airway reactions in different asthmatic patients.Thus promoting the persistence of inflammation and the deterioration of airway remodeling.This article summarizes the effects of epigenetic modification of ASM on asthma.