康妇炎胶囊联合替硝唑治疗卵巢囊肿的临床研究

Clinical study of Kangfuyan Capsules combined with tinidazole in treatment of ovarian cyst

目的探讨康妇炎胶囊联合替硝唑对卵巢囊肿患者的临床疗效和各激素水平的影响。方法选取2017年1月—2019年1月汉中市人民医院90例卵巢囊肿患者作为研究对象。根据就诊单双号将患者分为对照组和观察组,每组各45例。对照组患者静脉滴注替硝唑氯化钠注射液,400 mg,1次/d,经期停药。观察组患者在对照组的基础上口服康妇炎胶囊,3粒/次,2次/d,经期停药。两组均连续治疗2周。观察两组患者的临床疗效,同时比较两组治疗前后的中医症状评分、一氧化氮(NO)、肿瘤坏死因子-α(TNF-α)水平、各激素水平和囊肿直径。结果治疗后,观察组患者总有效率为93.33%,对照组患者总有效率为77.78%,两组比较存在统计学差异(P<0.05)。治疗后,两组患者症状积分、NO和TNF-α水平均显著降低(P<0.05);且观察组症状积分、NO和TNF-α水平均显著低于对照组(P<0.05)。治疗后,两组患者抗苗勒试管激素(AMH)、孕酮(P)、雌二醇(E2)和囊肿直径均明显降低,促黄体生成素(LH)/卵泡雌激素(FSH)显著升高(P<0.05);且观察组各激素水平和囊肿直径显著优于对照组(P<0.05)。结论康妇炎胶囊联合替硝唑可有效改善卵巢囊肿患者各激素水平,缓解患者的临床症状,疗效确切,在卵巢囊肿治疗中具有较高的应用价值。

Objective To investigate the clinical effect of Kangfuyan Capsules combined with tinidazole in treatment of ovarian cyst, and the influence of hormone levels.Methods A total of 90 cases patients with ovarian cysts in Hanzhong People’s Hospital from January 2017 to January 2019 were selected as research objects.And the patients were divided into the control group and the observation group according to the odd or even number of patients.There were 45 patients in each group.Patients in the control group were iv administered with Tinidazole and Sodium Chloride Injection 400 mg, once daily, and stopped taking the drug during menstruation.Patients in the observation group were po administered with Kangfuyan Capsules on the basis of control group, 3 grains/time, twice daily, menstrual withdrawal.Both groups were treated continuously for 2 weeks.After treatment, the clinical efficacy in two groups was observed, and the TCM symptom scores, the levels of NO and TNF-α levels,hormone levels, and cyst diameter of two groups were compared before and after treatment.Results After treatment, the total effective rate was 93.33% in the observation group and 77.78% in the control group, showing statistical difference between the two groups(P < 0.05).After treatment, the symptom scores, NO and TNF-α levels in two groups were decreased(P < 0.05).In addition, symptom score, NO and TNF-α levels in the observation group were significantly lower than those in the control group(P < 0.05).After treatment, AMH, P, E2, and cyst diameter were significantly decreased in two groups, while LH/FSH was significantly increased(P < 0.05).The hormone levels and cyst diameter of the observation group were significantly better than those of the control group(P < 0.05).Conclusion Kangfuyan Capsules combined with tinidazole can effectively improve the levels of hormones in patients with ovarian cyst, relieve the clinical symptoms, with a definite curative effect, and has a high application value in the treatment of ovarian cyst.