利奈唑胺联合布地奈德治疗儿童肺炎的效果观察

Effect of linezolid combined with budesonide in treatment of pneumonia in children

目的研究利奈唑胺联合布地奈德治疗儿童肺炎的临床疗效。方法选择2016年1月—2019年1月安康市中心医院的90例肺炎患儿作为研究对象,采用抽签法随机将患儿分为对照组和观察组,每组各45例。对照组患儿雾化吸入布地奈德气雾剂,500μg/d,2次/d。观察组在对照组的基础上静脉滴注利奈唑胺注射液,10 mg/kg,2次/d,连续给药10 d,当患儿的病情稳定后,改为口服利奈唑胺片,10 mg/kg。两组疗程均为3周。观察两组患儿的临床疗效、住院时间及症状消失时间,同时比较两组治疗前后的总免疫球蛋白(Ig)E(T-IgE)和嗜酸性粒细胞(EOS)水平。结果治疗后,观察组的总有效率为95.55%,明显高于对照组的77.78%(P<0.05)。治疗后,观察组的住院时间和发热、肺部湿啰音、咳嗽消失时间明显短于对照组(P<0.05)。两组治疗后EOS水平均显著降低(P<0.05),且观察组治疗后的EOS水平明显低于对照组(P<0.05),TIgE无明显改变。结论利奈唑胺联合布地奈德对儿童肺炎具有比较确切的治疗效果,能缩短住院时间及症状消失时间,减轻气道炎症性反应,具有一定的临床推广应用价值。

Objective To study the effect of linezolid combined with budesonide in treatment of pneumonia in children.Methods A total of 90 children with pneumonia in Ankang Central Hospital from January 2016 to January 2019 were selected as the research objects, and randomly divided into control group and observation group by lottery, with 45 patients in each group.Patients in the control group were inhaled Budesonide Aerosol, 500 μg/d, twice daily.Patients in the observation group were iv administered with Linezolid Injection on the basis of control group, 10 mg/kg, twice daily for 10 days consecutively.When the condition of the children was stable, they were changed to oral Linezolid Tablets for 10 mg/kg.The course of treatment in two groups was 3 weeks.After treatment, the clinical efficacy, length of hospital stay and time of symptom disappearance in two groups were observed, and the T-IgE and EOS levels before and after treatment were compared.Results After treatment, the total effective rate of the observation group was 95.55%, which was significantly higher than 77.78% of the control group(P < 0.05).After treatment, the length of stay in the observation group and the disappearance time of fever, lung rales and cough were significantly shorter than those in the control group(P < 0.05).After treatment, EOS level in two groups was significantly decreased(P < 0.05), and the EOS level in the observation group was significantly lower than that in the control group(P < 0.05), while there was no significant change in T-IgE.Conclusion Linezolid combined with budesonide has a relatively accurate therapeutic effect on children with pneumonia,can shorten the length of hospital stay and the disappearance of symptoms, reduce airway inflammatory response, and has certain clinical promotion and application value.