腺苷负荷对健康家兔左室心肌应变力学的影响

Effects of adenosine stress on left ventricular myocardial strain mechanics in healthy rabbits

目的探讨运用斑点追踪超声结合腺苷负荷评价生理状态健康家兔心肌应变力学的变化特点。方法对20只健康家兔在静息状态和腺苷负荷状态行斑点追踪超声心动图检查,采集左室短轴及心尖长轴标准切面的连续3个心动周期的动态原始图像,并使用Echo PAC工作站进行后处理分析,测量静息及腺苷负荷状态下左室整体纵向峰值应变、整体圆周峰值应变和整体径向峰值应变。结果静息及负荷状态下,家兔心率、左室各结构及功能参数之间差异无统计学意义(均P>0.05);腺苷负荷后左室整体纵向峰值应变及圆周峰值应变较静息状态显著增加(P<0.001),而整体径向峰值应变未见明显增加(P>0.05)。结论腺苷负荷超声心动图结合斑点追踪超声可评估家兔生理状态下心肌应变力学的变化特点,为未来腺苷负荷超声心动图在家兔心血管疾病模型中的应用提供了参考。

Objective To explore the changes of myocardial strain mechanics in healthy rabbits in the physiological condition by using speckle tracking echocardiography(STE)combined with adenosine stress.Methods Twenty healthy rabbits underwent STE both at rest and during adenosine stress.The dynamic original images of 3 consecutive cardiac cycles of the standard views from the left ventricular(LV)short axis and apical long axis were acquired and analyzed by the Echo PAC workstation.The procedure was performed to obtain LV global longitudinal peak strain,global circumferential peak strain,and global radial peak strain both at rest and during adenosine stress.Results There were no significant differences in heart rate and LV structural and functional parameters between baseline and adenosine stress(P>0.05).After adenosine stress,LV global longitudinal peak strain and global circumferential peak strain increased significantly when compared with those at rest(P<0.001),while LV global radial peak strain did not change significantly(P>0.05).Conclusions Adenosine stress echocardiography combined with STE can be used to evaluate the characteristics of myocardial strain mechanics in rabbits in the physiological condition.This research provides reference value for the application of adenosine stress echocardiography in rabbit models with cardiovascular disease in future.