丹毒样皮肤转移癌临床和文献分析

Clinical and literature analysis of metastatic carcinoma erysipeloides

皮肤转移癌多为单发或多发坚实结节。该文报道2例少见的源于乳腺癌和肺癌皮肤转移,表现为丹毒样癌(carcinoma erysipeloides)的患者。结合文献报道对丹毒样皮肤转移癌的原发肿瘤进行了归纳分析,提示丹毒样癌与其他皮肤转移癌一样,腺癌可能是其主要来源,腺癌细胞与真皮淋巴管可能存在某种特殊粘附机制,淋巴管阻塞为癌细胞免疫逃逸提供了机会。

Clinical manifestations of cutaneous metastases present usually as either solitary or multiple firm, mobile nodules. Here we reported two cases of carcinoma erysipeloides secondary to internal malignant tumor and reviewed the literature data. The analysis results indicated that adenocarcinoma may be the commonest cause of carcinoma erysipeloides, similar to the other types of cutaneous metastases. The adenocarcinoma cells can grasped the dermal lymphatic endotheliocytes by the special adhesion molecules. The lumina of dermal lymphatic vessels were blocked so that the adenocarcinoma cells can avoid the attacks of lymphocytes.