咖啡因联合肺表面活性物质预防50例早产儿支气管肺发育不良

Caffeine combined with pulmonary surfactant for the prevention of bronchopulmonary dysplasia in 50 premature infants

目的:探讨咖啡因联合肺表面活性物质预防早产儿支气管肺发育不良的作用。方法:回顾性选取胎龄<32周、年龄初生至6 h的早产儿100例,依据治疗方法分为干预组(n=50)和对照组(n=50)。两组予常规治疗,对照组仅给予肺表面活性物质,干预组给予肺表面活性物质+咖啡因。比较两组血气分析、呼吸暂停时间、吸氧时间、机械通气时间、住院时间和支气管肺发育不良发生情况。结果:干预组治疗后较治疗前的PO2、pH、FiO2升高幅度、PCO2降低幅度均显著高于对照组(P<0.05);呼吸暂停时间、吸氧时间、机械通气时间和住院时间均显著短于对照组(P<0.05);支气管肺发育不良发生率显著低于对照组(P<0.05)。结论:采用咖啡因联合肺表面活性物质预防早产儿支气管肺发育不良的作用较单独肺表面活性物质显著。

Objective:To investigate the effect of caffeine combined with pulmonary surfactant on the prevention of bronchopulmonary dysplasia in premature infants.Methods:A total of 100 premature infants(<32 weeks gestational age and 6 hours gestational age)were randomly divided into an intervention group(n=50)and a control group(n=50).The two groups were given routine treatment,while the control group was given only pulmonary surfactant,and the intervention group was given pulmonary surfactant+caffeine.Blood gas analysis,apnea time,oxygen inhalation time,mechanical ventilation time,hospitalization time and bronchopulmonary dysplasia were compared between the two groups.Results:The levels of PO2,pH,FiO2 and PCO2 were significantly higher,the times for apnea,oxygen inhalation,mechanical ventilation and hospitalization were significantly shorter and the incidence of bronchopulmonary dysplasia was significantly lower in the intervention group than the control group(P<0.05).Conclusion:The effect of caffeine combined with pulmonary surfactant on the prevention of bronchopulmonary dysplasia in preterm infants is significantly higher than that of pulmonary surfactant alone.