维生素D在妇科良恶性肿瘤患者中表达水平的分析

Analysis of Expression Level of Vitamin D in Patients With Gynecological Benign and Malignant Tumors

目的探讨正常成年女性与妇科良、恶性肿瘤患者血清中25-羟维生素D水平的变化及临床意义。方法随机选择2019年2-11月到南京市妇幼保健院健康体检的145例正常女性、就诊的139例妇科良性肿瘤患者和144例妇科恶性肿瘤患者分为正常对照组、妇科良性肿瘤组、妇科恶性肿瘤组。采集其外周血液样本,应用Cobas6000检测样本中25-羟维生素D的水平。分析正常女性与妇科良恶性肿瘤患者体内25-羟维生素D水平的变化。结果正常对照组血清25-羟维生素D水平为(19.38±4.74)ng/mL,妇科良性肿瘤组血清25-羟维生素D水平为(19.88±4.93)ng/mL,妇科恶性肿瘤组血清25-羟维生素D水平为(11.48±2.71)ng/mL。血清25-羟维生素D在妇科恶性肿瘤组的水平低于正常女性组及妇科良性肿瘤组,差异有统计学意义(P<0.05),而血清25-羟维生素D在正常女性组与妇科良性肿瘤组的表达差异无统计学意义(P>0.05)。结论维生素D的缺乏与妇科恶性肿瘤的发生具有相关性,提示25-羟维生素D对妇科恶性肿瘤的治疗可能具有一定的临床意义。

Objective To investigate the changes and clinical significance of serum 25-hydroxyvitamin D levels in normal adult women and patients with gynecological benign and malignant tumors.Method 145 normal women,139 patients with benign gynecological tumors and 144 patients with malignant gynecological tumors were randomly selected from February to November 2019 for physical examination in Nanjing Maternal and Child Health Hospital.They were divided into normal control group,benign gynecological tumors group and malignant gynecological tumors group.Peripheral blood samples were collected and the level of 25-hydroxyvitamin D was detected by Cobas6000 and 25-hydroxyvitamin D levels in normal women and patients with gynecological benign and malignant tumors were analysed.Result 25-hydroxyvitamin D level in normal control group was(19.38±4.74)ng/mL,25-hydroxyvitamin D level in benign gynecological tumors group was(19.88±4.93)ng/mL,25-hydroxyvitamin D level in gynecological malignant tumors group was(11.48±2.71)ng/mL.25-hydroxyvitamin D level in gynecological malignant tumors group was significantly lower than that in normal control group and benign gynecological tumors group,the difference was statistically significant(P<0.05).There was no significant difference in 25-hydroxyvitamin D expression between normal control group and benign gynecological tumors group(P>0.05).Conclusion Vitamin D deficiency is associated with the occurrence of gynecological malignant tumors,suggesting that 25-hydroxyvitamin D may have certain clinical significance in the treatment of gynecological malignant tumors.