川崎病合并冠状动脉病变危险因素分析

Risk Factors of Kawasaki Disease Complicated With Coronary Artery Disease

目的分析小儿川崎病合并冠状动脉病变危险因素分析。方法随机选取医院2014年1月-2019年3月收诊的川崎病患儿80例,根据是否并发冠状动脉病变将其分成对照组与研究组,分别为58例、22例。采用回顾分析法对两组患儿病案进行分析,统计两组患儿性别、年龄、疾病诊断、生化学指标[红细胞沉降率(ESR)、血小板计数(PLT)、血红蛋白(Hb)、C反应蛋白(CRP)、白细胞计数(WBC)]、发热时间、丙种球蛋白(IVIG)开始使用时间。经单因素分析后对有统计学意义的变量进行多因素Logistic回归分析。结果两组患儿ESR、PLT、IVIG开始使用时间、WBC、Hb、发热时间差异比较有统计学意义(P<0.05),CRP差异比较无统计学意义(P>0.05)。其中ESR、IVIG开始使用时间是川崎病合并冠状动脉病变独立危险因素。结论ESR、IVIG开始使用时间是影响川崎病合并冠状动脉病变的独立危险因素,临床应积极干预,预防冠状动脉病变发生。

Objective This paper mainly analyzed the risk factors of pediatric Kawasaki disease with coronary artery disease.Methods A total of 80 children with kawasaki disease admitted to the hospital from January 2014 to March 2019 were randomly selected and divided into a control group and a study group according to whether coronary artery disease was complicated or not.The cases were 58 and 22,respectively.The retrospective analysis method was used to analyze the medical records of the two groups of children,and the gender,age,disease diagnosis,biochemical indicators[erythrocyte sedimentation rate(ESR),platelet count(PLT),hemoglobin and c-reactive protein(Hb),C-reactive protein(CRP),and white blood cell count(WBC)],fever time and starting time of immunoglobulin(IVIG)in the two groups were counted.After univariate analysis,multivariate Logistic regression analysis was performed for statistically significant variables.Results There were statistically significant differences in ESR,PLT,starting time of IVIG,WBC,Hb and fever time between the two groups(P<0.05),but no statistically significant differences in CRP(P>0.05).The starting time of ESR and IVIG were independent risk factors for Kawasaki disease with coronary artery disease.Conclusion The starting time of ESR and IVIG is an independent risk factor for Kawasaki disease complicated with coronary artery disease,and clinical intervention should be actively conducted to prevent the occurrence of coronary artery disease.