摘要
Thy-1 as an“anti-sprouting”factor:Since the identification of Thy-1(CD-90)in 1964 by Reif and Allen,the precise functions of this glycosyl phosphatidylinositol-anchored surface protein within the central nervous system have been difficult to characterize.Thy-1 is a 110-amino acid cellular adhesion molecule that plays a role in cell-cell communication by interacting with other cellular adhesion molecules,including integrins(Leyton et al.,2001).While found on a diverse array of cells within the body,Thy-1 is present on the surface of almost every neuron in the brain(Morris and Grosveld,1989).
