Th17细胞与脂肪胰岛素抵抗关系研究

Study on relationship between Th17 cells and adipose insulin resistance

脂肪胰岛素抵抗(AIR)是多种代谢相关疾病发生的核心病因。而脂肪组织的炎症是形成AIR的主要原因之一。辅助性T细胞17(Th17细胞)是近年新发现的Th亚群,其分泌的白细胞介素(IL)-17、IL-22等是重要的促炎细胞因子。越来越多的证据表明,Th17细胞在AIR的形成中发挥关键作用,因此,本文就二者关系进行综述,探讨其潜在的治疗靶点。

Adipose insulin resistance(AIR)is the core cause of various metabolic related diseases occurrence.The inflammation of fat tissue is one of the main reasons for the formation of AIR.Helper T cells 17(Th17 cells)are the newly discovered subgroup of T helper cells in recent years.Interleukin 17(IL-17)and interleukin 22(IL-22)secreted by Th17 cells are the important proinflammatory cytokines.More and more evidences show that Th17 cells play a key role in the formation of AIR.Therefore,this article reviews the relationship between the them and discusses their potential therapeutic targets.