基于单核/巨噬细胞功能调节的急性肝衰竭的免疫治疗策略

Immunotherapy strategies for acute liver failure based on monocyte/macrophage function regulation

急性肝衰竭(ALF)是一种病死率极高的临床综合征,其发生突然,病程发展迅速,病情复杂多变。尽管ALF是多种因素综合作用的结果,但其核心环节是大量的肝细胞死亡,且机体免疫介导的继发性肝损伤是ALF发生重要的机制之一。单核/巨噬细胞功能障碍是ALF疾病进展的关键,并且巨噬细胞还参与了驱动损伤和相关炎症的发生、传播和消退的过程。更好地理解ALF中单核/巨噬细胞发挥的作用及调节巨噬细胞可塑性的机制,将会为ALF的免疫治疗策略提供新的理论支持。

Acute liver failure(ALF)is a clinical syndrome with extremely high mortality.It occurs suddenly,develops rapidly and the disease condition is complex and changeable.ALF is the result of combination action of multiple factors,but its core link is massive hepatocytes necrosis,moreover the secondary immune-mediated liver injury is one of important mechanisms in the occurrence of ALF.The monocyte/macrophage dysfunction is the key to the development of ALF.Macrophages are also involved in the processes of occurrence,transmission and regression of driving injury and related inflammation.Better understanding of the role of monocytes/macrophages in ALF and the mechanisms of regulating macrophage plasticity will provide new theoretical support for the immunotherapy strategies of ALF.