腔隙性脑梗死患者血管周围间隙扩大与颅内外动脉粥样硬化性狭窄的相关性分析

Correlation Analysis Between Perivascular Space Enlargement andIntracranial Atherosclerotic Stenosis in Patients with Lacunar CerebralInfarction

目的探讨腔隙性脑梗死患者血管周围间隙扩大与颅内外动脉粥样硬化性狭窄的相关性分析。方法选取广州市增城区人民医院2018年6月至2019年4月收治的100例腔隙性脑梗死患者作为研究对象,按照病理类型将其分为对照组和研究组,各50例。仅有血管周围间隙扩大为对照组,血管周围间隙扩大与颅内外动脉粥样硬化性狭窄为研究组,收集两组患者的相关资料,探究腔隙性脑梗死患者血管周围间隙扩大与颅内外动脉粥样硬化性狭窄的相关性。结果研究组C反应蛋白(CRP),血清总胆固醇(TC)、甘油三酰(TG)、低密度脂蛋白(LDL-C)均高于对照组,高密度脂蛋白(HDL-C)低于对照组,差异有统计学意义(P<0.05);对上述指标进行logostic回归分析表明,患者的CRP、TC、TG、LDL-C、HDL-C为血管周围间隙扩大相关因素。结论腔隙性脑梗死患者中,其血管周围间隙扩大与其颅内外动脉粥样硬化性狭窄存在一定的相关性,故而在临床治疗过程中,应联合降脂药物对患者进行治疗,以改善其临床症状。

Objective To investigate the relationship between the enlargement of perivascular space and atherosclerotic stenosis in patients with lacunar infarction.Methods A total of 100 patients with lacunar infarction in People's Hospital,Zengcheng District from June 2018 to April 2019 were selected as the research objects.According to the pathological types,they were divided into two groups:the control group and the study group Objective to explore the correlation between the enlargement of perivascular space and atherosclerotic stenosis in patients with lacunar infarction.Results The levels of C-reactive protein(CRP),blood lipid,serum total cholesterol(TC),triglyceride(TG),low-density lipoprotein(LDL-C)in the study group were higher than those in the control group,while the high-density lipoprotein(HDL-C)was lower than that in the control group(P<0.05).The above indicators were analyzed by logistic regression analysis,which showed that the CRP,TG and LDL-C of the patients were significantly higher than those of the control group(P<0.05)TC,TG,LDL-C and HDL-C were related factors of perivascular space enlargement.Conclusion In patients with lacunar cerebral infarction,there is a certain correlation between the enlargement of perivascular space and the atherosclerotic stenosis of intracranial and extracranial.Therefore,in the process of clinical treatment,lipid-lowering drugs should be combined to improve the clinical symptoms.