茵陈蒿汤联合恩替卡韦治疗慢性乙型肝炎急性发作的临床疗效观察

Clinical Observation of Yinchenhao Decoction Combined with Entecavir inTreating Acute Attack of Chronic Hepatitis B

目的分析茵陈蒿汤联合恩替卡韦治疗慢性乙型肝炎急性发作的临床疗效。方法回顾分析梅州市大埔县人民医院2018年2月至2019年12月收治的乙型肝炎急性发作患者60例,按治疗方式分为对照组和观察组,各30例。对照组接受恩替卡韦治疗,观察组接受茵陈蒿汤联合恩替卡韦治疗,比较两组治疗效果、肝功能指标等。结果观察组治疗有效率96.67%高于对照组70.00%,差异有统计学意义(P<0.05);治疗前组间肝功能指标比较,差异无统计学意义(P>0.05),治疗后,观察组γ-谷氨酰转肽酶(GGT)、谷草转氨酶(AST)、总胆红素(TBIL)、谷丙转氨酶(ALT)低于对照组,白蛋白(ALB)高于对照组,差异有统计学意义(P<0.05)。结论临床治疗慢性乙型肝炎急性发作,可在恩替卡韦基础上给予茵陈蒿汤,此方法对患者肝功能恢复有促进作用,进而提升疗效。

Objective To analyze the clinical efficacy of Yinchenhao Decoction combined with entecavir in the treatment of acute exacerbation of chronic hepatitis B.Methods Totally 60 patients with acute hepatitis B attack admitted to People's Hospital of Dapu County of Meizhou city from February 2018 to December 2019 were retrospectively analyzed.According to the treatment methods,30 patients were treated with entecavir(control group),and the other 30 patients were treated with Yinchenhao Decoction combined with entecavir(observation group).The therapeutic effects,such as curative effect and liver function indexes,were compared.Results The curative effect of the observation group was 96.67%higher than that of the control group 70.00%,the difference was statistically significant(P<0.05);before treatment,there was no significant difference in liver functionindexes between the two groups(P>0.05). After treatment,GGT,AST,TBIL,ALT in the observation group were lowerthan those in the control group,and ALB was higher than that in the control group,the difference was statisticallysignificant(P<0.05). Conclusion Clinical treatment of acute exacerbation of chronic hepatitis B can be basedon entecavir,and then given Yinchenhao Decoction. This method can promote the recovery of liver function ofpatients,and then improve the curative effect.