拉莫三嗪片致重症多形性红斑1例分析

One Case of Lamotrigine-induced Severe Erythema Multiforme Drug Eruption

目的探讨拉莫三嗪致重症多形性红斑的处置措施。方法分析1例拉莫三嗪致重症多形性红斑的诊疗经过,结合文献检索,探讨拉莫三嗪致重症多形性红斑的机制和应对措施。结果患者服用拉莫三嗪第55天诊断为重症多形性红斑,立即停用并静脉滴注甲泼尼龙琥珀酸钠等相关治疗,患者病情逐步好转。停药第19天,患者皮疹明显好转,瘙痒感消失。结论拉莫三嗪致重症多形性红斑应立即停药,给予糖皮质激素等对症治疗。

Objective To explore ways to treat Stevens Johnson syndrome induced by lamotrigine.Methods The diagnosis and treatment of one case of Stevens Johnson syndrome induced by lamotrigine was analyzed.The mechanism by which lamotrigine induced Stevens Johnson syndrome was discussed in combination with literature.Results The patient was diagnosed with Stevens Johnson syndrome on the 55th day he took lamotrigine.The drug was stopped immediately.His condition gradually improved after the treatment with intravenous methylprednisolone sodium succinate.Skin rash was significantly improved,and itching disappeared on the 19th day of withdrawal.Conclusion The use of lamotrigine should be stopped immediately should Stevens Johnson syndrome occur.Glucocorticoid and other drugs should be given as symptomatic treatment.