血清IL-6、CRP联合PCT与脓毒症患者危重程度及预后的相关性分析

Correlation Analysis of IL-6 and CRP Combined with PCT of Serum with the Severity and Prognosis of Sepsis Patients

该文旨在分析血清IL-6和CRP联合PCT的检测在评估脓毒症患者的危重程度及预后情况中的应用价值。选取2016年12月1日至2019年12月1日于我院就诊的106例脓毒症患者,在患者入院24 h内进行血清IL-6、CRP和PCT水平检测,同时进行SOFA评分。患者入院后28天内,根据生存结局将患者分为生存组和死亡组,并判断患者是否合并MODS。分析患者血清IL-6、CRP和PCT水平与危重程度及预后的相关性。与生存组相比,死亡组患者血清IL-6、CRP和PCT水平均更高,差异具有统计学意义(P<0.05)。死亡组患者合并MODS的比例高于生存组,差异具有统计学意义(P<0.05)。IL-6、CRP和PCT 3项指标联合检测的效果要优于任一单独指标检测。患者血清IL-6、CRP和PCT水平与SOFA评分及不良预后呈正相关。血清IL-6、CRP联合PCT水平可用于评估毒症患者的危重程度及预后情况,具有较高的临床应用价值。

This study aimed to study the value of serum levels of IL-6 and CRP combined with procalcitonin in evaluating the severity and prognosis of sepsis patients.A total of 106 patients with sepsis admitted to our hospital from December 1,2016 to December 1,2019 were selected.Serum levels of IL-6,CRP and PCT were detected within 24 h upon admission,and SOFA score was also performed.Within 28 days after admission,the patients were divided into the survival group and the death group according to the survival outcome,and the patients were judged whether they had MODS(multiple organ dysfunction syndrome).The correlation between serum levels of IL-6,CRP and PCT and severity and prognosis was detected.Compared with the survival group,the serum levels of IL-6,CRP and PCT in the death group were higher on average,with statistically significant differences(P<0.05).The proportion of patients with MODS in the death group was higher than that in the survival group,and the difference was statistically significant(P<0.05).The results of the combined detection of IL-6,CRP and PCT were better than those of any single indicator.Serum levels of IL-6,CRP and PCT were positively correlated with SOFA score and the rate of poor prognosis.Serum IL-6,CRP combined with PCT level has clinical value in predicting the severity and prognosis of sepsis patients.