复方丹参注射液联合丁苯酞治疗对缺血性脑卒中神经功能缺损和血小板活化状态的影响

The effects of compound danshen injection combined with butylphthalide on neurological deficits and platelet activation status in ischemic apoplexy

目的探讨复方丹参注射液联合丁苯酞治疗对缺血性脑卒中神经功能缺损和血小板活化状态的影响。方法选择84例缺血性脑卒中患者,按照简单随机分组分为对照组和研究组各42例,在常规治疗基础上,对照组加用丁苯酞注射液静脉滴注,研究组加用丁苯酞注射液、复方丹参注射液静脉滴注,分析两组疗效、神经功能缺损评分[美国国立卫生研究院卒中量表(NIHSS评分)]、血小板活化状态指标[P-选择素(CD62P)、血小板凝溶胶蛋白(GSN)、血小板膜糖蛋白纤维蛋白原受体(PAC-1)]水平及不良反应的差异。结果研究组治疗总有效率高于对照组(P<0.05);治疗前至治疗14天,两组NIHSS评分逐渐降低,且研究组治疗7、14天的NIHSS评分均低于对照组(P<0.05);治疗后,两组CD62P、PAC-1水平均降低,GSN水平升高,且研究组CD62P、PAC-1水平低于对照组,GSN水平高于对照组(P<0.05);两组药物不良反应发生率比较差异无统计学意义(P>0.05)。结论缺血性脑卒中患者应用复方丹参注射液联合丁苯酞方案治疗疗效显著,在改善患者神经功能缺损及血小板活化状态方面优势明显,安全性高。

Objective To explore the effects of compound danshen injection combined with butylphthalide on neurological deficits and platelet activation status in patients with ischemic apoplexy.Methods Eighty-four patients with ischemic apoplexy were selected and randomly divided into control or study group,42 in each group.On the basis of routine treatment,the control group was given intravenous drip of butylphthalide injection,and the study group was given intravenous drip of butylphthalide injection and compound danshen injection.The efficacy,score of neurological deficits such as National Institutes of Health Stroke Scale(NIHSS score),levels of platelet activation status indicators such as P-selectin(CD62P),platelet gelsolin(GSN)and platelet membrane glycoprotein fibrinogen receptor(PAC-1)and adverse reactions were analyzed in the two groups.Results The total effective rate of treatment in the study group was significantly higher than that in the control group(P<0.05).Before treatment to 14 days after treatment,the NIHSS score of the two groups showed a significant downward trend(P<0.05),and the NIHSS scores in the study group on the 7 th and the 14 th day after treatment were significantly lower than those in the control group(P<0.05).After treatment,the levels of CD62P and PAC-1 were significantly reduced while the GSN level was significantly increased in both groups,and the levels of CD62P and PAC-1 were lower while the level of GSN was higher in the study group than those in the control group(P<0.05).There was no statistically significant difference in the incidence rate of adverse drug reactions between the two groups(P>0.05).Conclusion Compound danshen injection combined with butylphthalide has a significant efficacy in the treatment of patients with ischemic apoplexy.It has obvious advantages in improving neurological deficits and platelet activation status with high safety.