446例精神分裂症门诊患者血药浓度监测与分析

Analysis of 446 outpatients’serum drug concentration monitoring results in psychiatric hospital

目的收集门诊患者的血药浓度的监测结果,分析门诊患者在血药浓度监测过程中各因素对结果的影响,为临床医生提供更合理的血药浓度监测结果。方法选择2018年11月~2019年3月苏州市广济医院监测的门诊患者的血药浓度446例,将血药浓度结果、给药剂量、性别和年龄等资料录入数据库,进行统计分析。结果在446例门诊患者中,19~35岁年龄段患者是血药浓度监测的主要人群,占52.91%;血药浓度在有效血药浓度范围内的占47.09%,低于有效血药浓度的占48.65%;出现了24例(5.38%)未检出血药浓度的情况。结论门诊患者不同于住院患者,其服药依从性、采血检测时间以及生活习惯等因素均可能对门诊患者血药浓度的结果产生影响,为此临床药师在提供药物咨询时应加强对门诊患者的服药情况问询,提高血药浓度监测结果解读的合理性,同时加强用药宣教,普及药品知识,提高门诊患者的用药认知。

Objective The purpose of this study was to analyze the factors which influence serum drug concentration of outpatients and by collecting the serum concentration monitoring results of outpatients in our hospital,which can provide more reasonable suggestions for clinicians.Methods The serum drug concentration of 446 outpatients monitored were selected from Suzhou Psychiatric Hospital during November in 2018 to March in 2019,and the data of serum drug concentration results,dose,gender and age were analyzed statistically.Results There were 446 cases of serum drug concentration monitoring in total.The main objects of serum drug concentration monitoring were range from 19 to 35 years old(52.91%).210 cases were in the effective serum drug concentration range accounted for 47.09%,217 cases were lower than the effective serum drug concentration accounted for 48.65%.There were 24 cases(5.38%)of undetected serum drug concentration.Conclusion Outpatients are different from inpatients.The factors such as medication compliance,blood collection time and lifestyle habits may affect the results of outpatients’serum drug concentration.Therefore,clinical pharmacists should strengthen the medication education for outpatients when providing medication consultation,which may improve the rationalisation of the serum drug concentration monitoring results,and at the same time strengthen medication consultation,popularize medication knowledge and raise medication awareness of outpatients.