血浆脂蛋白磷脂酶A2在2型糖尿病肾病患者的表达变化及临床意义

Expression and clinical significance of plasma lipoprotein phospholipase A2 in patients with type 2 diabetic nephropathy

目的探讨血浆脂蛋白磷脂酶A2在2型糖尿病肾病患者的表达变化及临床意义。方法选取2型糖尿病患者100例,根据尿白蛋白/肌酐比值(UACR)分为非DN组(UACR<30 mg/g)50例和DN组(UACR≤30 mg/g)50例,收集患者入院时的临床资料,包括年龄、UACR、肌酐(CREA)、尿酸(UA)、胱抑素C(CysC)、总胆固醇(TC)、脂蛋白磷脂酶A2(Lp-PLA2)、甘油三酯(TG)、低密度脂蛋白(LDL)、糖化血红蛋白(HbA1c)、空腹血糖(FBG)。并对检测结果进行统计学处理及比较分析。结果DN组Lp-PLA2活性、CREA、UA、CysC、TC、LDL、HbA1c显著高于非DN组,差异均有统计学意义(P<0.05),两组年龄、TG、FBG比较差异无统计学意义(P>0.05)。以DN组与非DN组作为整体进行相关性分析,Lp-PLA2与UA、TC、LDL、HbA1c成正相关(P<0.05)。结论Lp-PLA2作为新的特异性炎性标记物参与了糖尿病肾病的发生发展。实现良好的血糖控制可以减低Lp-PLA2活性、预防或延缓并发症的发生。

Objective To investigate the expression and clinical significance of plasma lipoprotein phospholipase A2 in patients with type 2 diabetic nephropathy.Methods A total of 100 patients with type 2 diabetes were selected and divided into the non-DN group(UACR<30mg/g)and the DN group(UACR≥30mg/g).Clinical data were collected,including age,urinary albumin creatinine ratio(UACR),creatinine(CREA),uric acid(UA),cystatin C(CysC),total cholesterol(TC),lipoprotein phospholipase A2(Lp-PLA2),triglyceride(TG),low density lipoprotein(LDL),HbA1c,and fasting blood glucose(FBG).The test results were statistically processed and compared.Results Lp-PLA2 activity,CREA,UA,CysC,TC,LDL and HbA1c in the DN group were significantly higher than those in the non-DN group,with statistically differences(P<0.05).There was no statistically difference in age,TG and FBG between the two groups(P>0.05).The correlation analysis of DN group and non-DN group as a whole showed that Lp-PLA2 was positively correlated with UA,TC,LDL and HbA1c(P<0.05).Conclusion Lp-PLA2 is involved in the development of diabetic nephropathy as a new specific inflammatory marker.Achieving good glycemic control can reduce Lp-PLA2 activity and prevent complications.