美托洛尔对冠心病心绞痛患者血脂代谢、心功能及不良反应的影响

Effects of Metoprolol on Blood Lipid Metabolism,Cardiac Function and Adverse Reactions in Coronary Heart Disease Patients with Angina Pectoris

目的:探讨美托洛尔对冠心病心绞痛患者血脂代谢、心功能及不良反应的影响。方法:选取2018年3月-2019年2月本院收治的88例冠心病心绞痛患者为研究对象,将其采用双色球抽签方式加以分组,对照组及观察组,每组44例,对照组给予常规药物治疗,观察组联合美托洛尔治疗,对比治疗前后的血脂代谢水平及心功能指标变化情况,记录两组出现的不良反应。结果:治疗前,两组患者的血脂水平检测差异无统计学意义(P>0.05);治疗后,两组患者的血脂水平检测结果显示均有所改善,且观察组TG、TC及LDL-C水平下降幅度更大,HDL-C水平提升幅度更大,差异均有统计学意义(P<0.05);治疗前,观察组心功能指标与对照组比较差异无统计学意义(p>0.05);治疗后,两组患者的心功能指标均得以改善,且观察组LVSD及LVDD较对照组下降幅度更大,LVEF提升幅度更大,差异均有统计学意义(P<0.05);观察组不良反应率4.55%,与对照组的18.18%比较,差异有统计学意义(P<0.05)。结论:针对冠心病心绞痛患者,美托洛尔能纠正患者的血脂异常情况,改善其血脂代谢,提高其心功能,且不良反应少,其有效性及安全性值得临床推广及使用。

Objective:To explore the effect of Metoprolol on blood lipid metabolism,cardiac function and adverse reactions in patients with coronary heart disease and angina pectoris.Method:A total of 88 patients with coronary heart disease and angina pectoris from March 2018 to February 2019 were selected as the study objects.They were divided into two groups by two color ball drawing,control group and observation group,44 cases in each group.The control group was given conventional drug treatment.The observation group was treated with Metoprolol,and the changes of blood lipid metabolism and heart function indexes before and after treatment were compared,and the adverse reactions of the two groups were recorded.Result:Before treatment,there was no significant difference in blood lipid level between the two groups (P>0.05);after treatment,the blood lipid level of the two groups showed improvement,and the TG,TC and LDL-C levels of the observation group decreased more,the HDL-C level increased more,the difference was statistically significant (P<0.05).Before treatment,the heart function indexes of the observation group and the control group had no significant difference (P>0.05);after treatment,the heart function indexes of the two groups were improved,and the LVSD and LVDD of the observation group decreased more than those of the control group,and the LVEF increased more significantly,the difference was statistically significant (P<0.05).The adverse reaction rate of the observation group was 4.55%,compared with the 18.18% of the control group,the difference was statistically significant (P<0.05).Conclusion:For patients with angina pectoris,Metoprolol can correct the abnormal situation of blood lipid,improve the metabolism of blood lipid,improve the heart function,and have fewer adverse reactions.Its effectiveness and safety are worth clinical promotion and use.