分子印迹比率荧光传感器的构建及应用

Construction and Application of Molecular Imprinted Ratiometric Fluorescence Sensor

分子印迹聚合物具有物理稳定性高、识别特异性强和易于设计合成等优势,与荧光传感相结合,能够实现对目标的高选择性和高灵敏度检测。相比单一荧光响应信号的分子印迹荧光传感器,双发射波长的分子印迹比率荧光传感器具有自我校正能力,可以有效地降低环境因素的影响并提高检测灵敏度。结合量子点、有机染料、金属纳米簇以及稀土元素螯合物等荧光信号,介绍了分子印迹比率荧光传感器的构建方法及应用,并对其研究前景进行了展望。

Molecular imprinted polymers possess the advantages of high physical stability,strong recognition specificity,and easy preparation.Combining with fluorescence sensing,highly selective and sensitive detection of targets can be achieved through the molecular imprinted fluorescent sensor.The molecular imprinted ratiometric fluorescence sensor with dual emission wavelengths has better self-correction capability than that of single-emission one,which enabling sensor to reduce the interference of environment and improve detection sensitivity.The construction and application of ratiometric fluorescencet imprinted polymer sensors are summarized based on various kinds of fluorophores,such as quantum dots,organic dyes,metal nanoclusters and rare earth chelates.Furthermore,the research prospects of molecularly imprinted ratiometric fluorescence sensors are also proposed.