2型糖尿病伴高尿酸血症患者危险因素的临床观察

Clinical observation on risk factors of type 2 diabetes mellitus with hyperuricemia

目的本研究旨在研究分析影响2型糖尿病(T2DM)并高尿酸血症(HUA)患者的危险因素。方法选择2018年3月—2019年8月本院收治的116例糖尿病患者作为研究对象,其中57例糖尿病合并高尿酸血症患者设为观察组,59例糖尿病未合并高尿酸血症患者设为对照组。收集其一般资料,分别测定其体重指数(BMI)、空腹血糖(FBG)、糖化血红蛋白(HbAlc)、血清总胆固醇(TC)、低密度脂蛋白(LDL-C)、甘油三酯(TG)、血肌酐(Cr)等生化指标。对比其临床资料,采用Logistic法回归分析影响T2DW并HUA的危险因素。结果观察组患者平均年龄为(63.4±13.20)岁,观察组的血清总胆固醇(4.99±1.20)、甘油三酯(2.79±1.91)、低密度脂蛋白(3.32±1.01)、体重指数(25.92±4.20)、血肌酐(86.48±37.13)情况均明显高于对照组患者,组间存在显著差异具有统计学意义(P<0.05);观察组患者合并脂肪肝的发生率为33.62%,对照组为24.14%,观察组高于对照组,组间存在明显差异(P<0.05)。结论糖尿病合并高尿酸血症患者的体重指数、血脂水平、血肌酐等明显高于不合并高尿酸血症的糖尿病患者,且患脂肪肝等并发症的患病率也明显高于对照组,对预测2型糖尿病并高尿酸血症的危险因素具有重要意义。

Objective To study the risk factors of patients with type 2 diabetes mellitus(T2 DM) complicated with hyperuricemia(HUA).Methods From March 2018 to August 2019,116 cases of type 2 diabetes mellitus patients admitted to our hospital were enrolled in the study.The 59 patients with type 2 diabetes only were selected as the control group and the other 57 patients with type 2 diabetes complicated with hyperuricemia were selected as the observation group.General information of patients,body mass index(BMI),fasting blood glucose(FBG),glycosylated hemoglobin(HbAlc),total cholesterol in serum(TC),low density lipoprotein-cholesterol(LDL-C),glycerin trilaurate(TG),serum creatinine(Cr) and other biochemical indexes were measured.The risk factors of T2 WDcomplicated with HUA were analyzed by logistic regression.Results The average age of patients WITH diabetes mellitus complicated with hyperuricemia was(63.4±13.20) years old.The serum total cholesterol(4.99±1.20),triglyceride(2.79±1.91),low-density lipoprotein(3.32±1.01),body mass index(25.92±4.20) and serum creatinine(86.48±37.13) in the observation group were significantly higher than those in the control group.There were significant difference between the two groups(P<0.05).The incidence of fatty liver was 33.62% in the observation group and 24.14% in the control group,the incidence of fatty liver in the observation group was significantly higher than that in the control group.Conclusions The body mass index,blood lipid level and serum creatinine of diabetes patients complicated with hyperuricemia were significantly higher than those of diabetes patients without hyperuricemia,and the prevalence of fatty liver and other complications was significantly higher than that of the control group,which is of great significance in predicting the risk factors of type 2 diabetes mellitus complicated with hyperuricemia.