术前血小板和淋巴细胞比值与结直肠癌临床病理特征和预后的关系

The relationship between preoperative platelet-to-lymphocyte ratio,clinicopathological features and prognosis of colorectal cancer

目的探讨术前血小板和淋巴细胞比值(PLR)与结直肠癌临床病理特征和预后的关系。方法选取2013年1月-2014年12月本院收治的128例结直肠癌患者,比较不同水平PLR值患者的临床病理资料,并分析影响结直肠癌患者预后的危险因素。结果与术前PLR高水平组比较,低水平组的TNM分期和脉管侵犯率更低,肿瘤分化程度越高,差异有统计学意义(P<0.05)。PLR高水平组的中位生存时间低于PLR低水平组,差异有统计学意义(49.2个月vs.60.9个月,P=0.006)。多因素分析结果显示,TNMⅢ期、中-低分化、脉管侵犯和术前PLR≥216.78水平是结直肠癌患者预后的独立危险因素(P<0.05)。结论术前PLR值与结直肠癌患者的临床病理特征相关,且是结直肠癌预后的独立危险因素。术前PLR值越高,预后越差。

Objective To explore the relationship between preoperative platelet-to-lymphocyte ratio,clinicopathological features and prognosis of colorectal cancer.Methods A total of 128 patients with colorectal cancer admitted to our hospital from Jan.2013 to Dec.2014 were selected.The clinical and pathological data of patients with different levels of PLR were compared,and the risk factors affecting the prognosis of patients with colorectal cancer were analyzed.Results Compared with the preoperative PLR high-level group,the TNM stage and vascular invasion rate in the low-level group were lower,and the degree of tumor differentiation was higher,with the difference statistically significant( P<0.05).The median survival time in PLR high-level group was significantly lower than that in PLR low-level group( 49.2 months vs.60.9 months,P=0.006).Multivariate analysis showed that TNM stage III,moderate to low differentiation,vascular invasion and preoperative PLR more than 216.78 were independent risk factors for prognosis of patients with colorectal cancer( P<0.05).Conclusion Preoperative PLR is associated with clinical and pathological features of colorectal cancer patients,and is an independent risk factor for prognosis of colorectal cancer.The higher the preoperative PLR,the worse the prognosis.