Rac1蛋白在结直肠癌中表达及其生物学行为的Meta分析

Expression and biological behavior of Rac1 protein in colorectal cancer:a Meta-analysis

目的系统评价Rac1蛋白在结直肠癌(CRC)中的表达及其生物学行为。方法在中国知网(CNKI)、万方数据库、中国生物医学文献数据库(CBM)、PubMed、Google Scholar数据库中搜索Rac1蛋白与CRC相关的研究文献,检索时间为1990年1月~2019年11月。采用Review Manager 5.3统计学软件进行Meta分析。结果最终纳入6项研究,共包含研究对象1011例。CRC组织中Rac1蛋白表达率高于癌旁正常组织,差异有统计学意义(OR=79.97,95%CI 4.65~1374.11,P=0.003)。Ⅰ、Ⅱ期CRC的Rac1蛋白表达率低于Ⅲ、Ⅳ期,差异有统计学意义(OR=0.26,95%CI 0.10~0.67,P=0.005)。低分化癌标本中的Rac1蛋白表达率高于中、高分化癌标本,差异有统计学意义(OR=2.51,95%CI 1.55~4.06,P=0.0002)。伴有淋巴结转移的CRC Rac1蛋白表达率高于无淋巴结转移,差异有统计学意义(OR=2.56,95%CI 1.36~4.82,P=0.004),且伴有远处转移的CRC Rac1蛋白表达率高于无远处转移,差异有统计学意义(OR=11.64,95%CI 5.71~23.70,P<0.00001)。结论Rac1蛋白表达与CRC的发生发展、浸润转移、预后等生物学行为密切相关。

Objective To systematically evaluate the expression and biological behavior of Rac1 protein in colorectal cancer(CRC).Methods Literatures were searched related to Rac1 protein and CRC from the databases of China National Knowledge Infrastructure(CNKI),Wanfang,China Biology Medicine disc(CBM),PubMed,Google Scholar.The retrieval time was from January 1990 to November 2019.Meta-analysis was performed using Review Manager 5.3.Results Finally,six literatures including 1011 cases were included.The expression rate of Rac1 protein in CRC was higher than that in normal tissues,with statistically significant difference(OR=79.97,95%CI 4.65-1374.11,P=0.003).The expression rate of Rac1 protein in stageⅠandⅡof CRC was lower than that in stageⅢandⅣ,with statistically significant difference(OR=0.26,95%CI 0.10-0.67,P=0.005).The expression rate of Rac1 protein in low differentiated cancer specimens was higher than that in high differentiated cancer specimens,with statistically significant difference(OR=2.51,95%CI 1.55-4.06,P=0.0002).The expression rate of Rac1 protein in CRC with lymph node metastasis was higher than that without lymph node metastasis,with statistically significant difference(OR=2.56,95%CI 1.36-4.82,P=0.004);and the expression rate of Rac1 protein in CRC with distant metastasis was higher than that without distant metastasis group,with statistically significant difference(OR=11.64,95%CI 5.71-23.70,P<0.00001).Conclusion Rac1 protein expression is closely related to the occurrence and development,invasion and metastasis,prognosis and other biological behaviors of CRC.