甲磺酸齐拉西酮注射液对精神分裂症急性激越症状患者PANSS-EC、BARS评分及不良反应的影响

Effect of Ziprasidone Mesylate Injection on PANSS-EC,BARS scores and adverse reactions in patients with acute agitation symptoms of schizophrenia

目的探讨甲磺酸齐拉西酮注射液对精神分裂症急性激越症状患者阳性和阴性症状量表兴奋因子(PANSS-EC)、行为活动评定量表(BARS)评分及不良反应的影响。方法回顾性分析2019年1月~2020年1月本院收治的67例精神分裂症急性激越症状患者的临床资料,按照不同治疗方式分为对照组(34例)和观察组(33例)。对照组给予氟哌啶醇注射液治疗,观察组采用甲磺酸齐拉西酮注射液治疗。比较两组的临床疗效、治疗前后PANSS-EC、BARS评分及不良反应总发生率。结果观察组的有效率为90.91%,与对照组的88.24%比较,差异无统计学意义(P>0.05);两组治疗后的PANSS-EC、BARS评分低于治疗前,差异有统计学意义(P<0.05);两组治疗后的PANSS-EC、BARS评分比较,差异无统计学意义(P>0.05);观察组的不良反应总发生率为9.09%,低于对照组的29.41%,差异有统计学意义(P<0.05)。结论甲磺酸齐拉西酮注射液治疗精神分裂症急性激越症状患者的治疗效果较好,其疗效与氟哌啶醇注射液相当,但不良反应发生率更低,安全性好。

Objective To investigate the effect of Ziprasidone Mesyate Injection on excited components of the positive and negative syndrome scale(PANSS-EC),behavioral activity rating scale(BARS)scores and adverse reactions in schizophrenia patients with acute agitation symptoms.Methods The clinical data of 67 schizophrenia patients with acute agitation symptoms who were admitted to our hospital from January 2019 to January 2020 were retrospectively analyzed.All the patients were divided into the control group(34 cases)and the observation group(33 cases)according to different treatment methods.The control group was given Haloperidol Injection,and the observation group was given Ziprasidone Meylate Injection.The clinical efficacy,PANSS-EC,BARS scores before and after treatment and the total incidence of adverse reactions were compared between the two groups.Results The effective rate of the observation group was 90.91%,compared with 88.24%of the control group,the difference was not statistically significant(P>0.05).The PANSS-EC and BARS scores in two groups after treatment were lower than those before treatment,the differences were statistically significant(P<0.05).There were no statistical differences in the PANSS-EC and BARS scores between the two groups after treatment(P>0.05).The total incidence rate of adverse reactions in the observation group(9.09%)was lower than that in the control group,the difference was statistically significant(29.41%)(P<0.05).Conclusion Ziprasidone Mesilate Injection in the treatment of schizophrenia patients with acute agitation symptoms has better curative effects,whose efficacy is similar to Haloperidol,but it has lower incidence of adverse reactions and better safety.